OPDC Publications

2017

3 themes

Theme1Dot Alexopoulou Z, Lang J, Perrett RM, Elschami M, Hurry ME, Kim HT, Mazaraki D, Szabo A, Kessler BM, Goldberg AL, Ansorge O, Fulga TA, Tofaris GK. (2017) Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease. Proc Natl Acad Sci USA. 113(32):E4688-97. PMID:2744401

Theme1Dot Baig F, Lawton MA, Rolinski M, Ruffmann C, Klein JC, Nithi K, Okai D, Ben-Shlomo Y, Hu MTM. (2017) Personality and addictive behaviours in early Parkinson’s disease and REM sleep behavior disorder. Park Rel Dis. 37:72-78. PMID:28173973

Theme2Dot Bailey J, Shaw A, Fischer R, Ryan BJ, Kessler BM, McCullagh J, Wade-Martins R, Channon KM, Crabtree MJ. (2017) A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance. Free Radic Biol Med. 104:214-225. PMID:28104455

 

Theme1Dot Barber TR, Lawton M, Rolinski M, Evetts S, Baig F, Ruffmann C, Gornall A, Klein JC, Lo C, Dennis G, Bandmann O, Quinnell T, Zaiwalla Z, Ben-Shlomo Y, Hu MT. (2017) Prodromal Parkinsonism and neurodegenerative risk stratification in REM sleep behaviour disorder. Sleep. PMID:28472425

Theme1Dot Barber TR, Klein JC, MacKay CE, Hu MT (2017) Neuroimaging in pre-motor Parkinson's disease. NeuroImage: Clinical 15, 215–227.

Theme2Dot Baud A, Wessely F, Mazzacuva F, McCormick J, Camuzeaux S, Heywood WE, Little D, Vowles J, Tuefferd M, Mosaku O, Lako M, Armstrong L, Webber C, Cader MZ, Peeters P, Gissen P, Cowley SA and Mills K. (2017) A Multiplex High-Throughput Targeted Proteomic Assay To Identify Induced Pluripotent Stem Cells. Analytical Chemistry. 89(4):2440-2448. PMID:28192931

Theme2Dot Beevers JE, Lai MC, Collins E, Booth HDE, Zambon F, Parkkinen L, Vowles J, Cowley SA, Wade-Martins R, Caffrey TM (2017) MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons. Stem Cell Reports. http://dx.doi.org/10.1016/j.stemcr.2017.06.005

Theme1Dot Bengoa-Vergniory N, Roberts RF, Wade-Martins R, Alegre-Abarrategui J. (2017) Alpha-synuclein oligomers: a new hope. Acta Neuropathol. PMID:28803412

Theme3Dot Brimblecombe KR, Cragg SJ (2017) The striosome and matrix compartments of the striatum: a path through the labyrinth from neurochemistry towards function. ACS Chem Neurosci. 8(2):235-242. PMID: 27977131

Theme2Dot Booth HDE, Hirst WD, Wade-Martins R. (2017) The Role of Astrocyte Dysfunction in Parkinson's Disease Pathogenesis. Trends Neurosci. 40(6):358-370. PMID:28527591

Theme1Dot Gan-Or Z, Montplaisir JY, Ross JY, Poirier J, Warby SC, Arnulf I, Strong S, Dauvilliers Y, Leblond CS, Hu MTM, Hogl B, Stefani A, Monaca CC, De Cock VC, Boivin M, Ferini-Stambi L, Plazzi G, Antelmi E, Young P, Heidbreber A, Barber TR, Evetts SG, Rolinski M, Dion PA, Desautels A, Gagnon J-F, Dupre N, Postuma RB, Rouleau GA. (2017) The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder. Neurobiology of Aging. 218.e13-218.e15. PMID: 27814994

Theme2Dot Haenseler W, Sansom SN, Buchrieser J, Newey SE, Moore CS, Nicholls FJ, Chintawar S, Schnell C, Antel JP, Allen ND, Cader MZ, Wade-Martins R, James WS, Cowley SA. (2017) A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response. Stem Cell Reports. 8(6):1727-1742. PMID:28591653

Theme2Dot Lee H, James WS, Cowley SA (2017) LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson’s disease. Biochemical Society Transactions. 45(1):131-139. PMID:28202666

Theme1Dot Malek N, Lawton MA, Grosset KA, Bajaj N, Barker RA, Ben-Shlomo Y, Burn DJ, Foltynie T, Hardy J, Morris HR, Williams NM, Wood N, Grosset DG; PRoBaND clinical consortium. (2017) Utility of the new Movement Disorder Society clinical diagnostic criteria for Parkinson's disease applied retrospectively in a large cohort study of recent onset cases. Parkinsonism Relat Disord. S1353-8020(17)30136-0. PMID:28431829

Theme2Dot Sandor C, Robertson P, Lang C, Heger A, Booth H, Vowles J, Witty L, Bowden R, Hu M, Cowley SA, Wade-Martins R, Webber C. (2017) Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease. Hum Mol Genet. 26(3):552-566. PMID: 28096185

Theme2Dot Sandor C, Honti F, Haerty W, Szewczyk-Krolikowski K, Tomlinson P, Evetts S, Millin S, Keane T, McCarthy S, Durbin R, Talbot K, Hu M, Webber C, Ponting C, Wade-Martins R. (2017) Whole-exome sequencing of 228 patients with sporadic Parkinson’s disease. Scientific Reports. 7:41188. PMID:28117402

Theme1Dot Silva de Lima AL, Evers LJ, Hahn T, Bataille L, Hamilton JL, Little MA, Okuma Y, Bloem BR, Faber MJ. (2017) Freezing of gait and fall detection in Parkinson's disease using wearable sensors: a systematic review. J Neurol. PMID:28251357

Theme1Dot Wei W, Keogh MJ, Wilson I, Coxhead J, Ryan S, Rollinson S, Griffin H, Kurzawa-Akanbi M, Santibanez-Koref M, Talbot K, Turner MR, McKenzie CA, Troakes C, Attems J, Smith C, Al Sarraj S, Morris CM, Ansorge O, Pickering-Brown S, Ironside JW, Chinnery PF. (2017) Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains. Acta Neuropathol Commun. 5(1):13. Erratum in: Acta Neuropathol Commun. 2017 Feb 22;5(1):17. PMID:28153046

Theme3Dot Wobst HJ, Denk F, Oliver PL, Livieratos A, Taylor TN, Knudsen MH, Bengoa-Vergniory N, Bannerman D and Wade-Martins R (2017) Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy. Scientific Reports. 7:43198. PMID:28233851

2016

3 themes

Theme1Dot Andrzejewski KL, Dowling AV, Stamler D, Felong TJ, Harris DA, Wong C, Cai H, Reilmann R, Little MA, Gwin J, Biglan KM, Dorsey ER (2016) Wearable sensors in huntington disease : a pilot study. Journal of Huntington's Disease. 5(2):199-206. PMID:27341134

Theme3Dot Dodson PDDreyer JK, Jennings KA, Syed ECWade-Martins RCragg SJBolam JPMagill PJ (2016) Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism. PNAS, 113(15):E2180-8. PMID: 27001837.

Theme1Dot Espay AJ, Bonato P, Nahab FB, Maetzler W, Dean JM, Klucken J, Eskofier BM, Merola A, Horak F, Lang AE, Reilmann R, Giuffrida J, Nieuwboer A, Horne M, Little MA, Litvan I, Simuni T, Dorsey ER, Burack MA, Kubota K, Kamondi A, Godinho C, Daneault JF, Mitsi G, Krinke L, Hausdorff JM, Bloem BR, Papapetropoulos S. (2016) Technology in Parkinson's disease: Challenges and opportunities. Movement Disorders. PMID:27125836

Theme1Dot Fairfoul G, McGuire LI, Pal S, Ironside JW, Neumann J, Christie S, Joachim C, Esiri M, Evetts SG, Rolinski M, Baig F, Ruffmann C, Wade-Martins R, Hu MTM, Parkkinen L and Green AJE (2016) Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies. Annals of Clinical and Translational Neurology. doi: 10.1002/acn3.338

Theme2Dot Fernandes HJR, Hartfield EM, Christian HC, Emmanoulidou E, Zheng Y, Booth H, Bogetofte H, Lang CRyan BJ, Sardi SP, Badger J, Vowles J, Evetts S, Tofaris GK, Vekrellis K, Talbot K, Hu MT, James W, Cowley SA, Wade-Martins R (2016) ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons. Stem Cell Reports. 6(3):342-56.  PMID:26905200

Theme3Dot Garas FN, Shah RS, Kormann E, Doig NM, Vinciati F, Nakamura KC, Dorst MC, Smith Y, Magill PJ, Sharott A. (2016)  Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons. Elife. 5. pii: e16088. PMID:27669410

Theme1Dot Griffanti L, Rolinski M, Szewczyk-Krolikowski K, Menke RA, Filippini N, Zamboni G, Jenkinson M, Hu MT, Mackay CE. (2016) Challenges in the reproducibility of clinical studies with resting state fMRI: An example in early Parkinson's disease. Neuroimage. 2016 Jan 1; 124(Pt A): 704–713. PMID:26386348

Theme2Dot Handel AEChintawar SLalic TWhiteley EVowles JGiustacchini AArgoud KSopp PNakanishi MBowden RCowley SNewey SAkerman CPonting CPCader MZ. (2016) Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single cell transcriptomics. Human Molecular Genetics. 25(5):989-1000. PMID: 26740550.

Theme2Dot Keane H, Ryan BJ, Jackson B, Whitmore A, Wade-Martins R. (2016) Protein-protein interaction networks identify targets which rescue the MPP+ cellular model of Parkinson's disease. Sci Rep. 5:17004. PMID:26608097

Theme3Dot Kosillo P, Zhang YF, Threlfell S, Cragg SJ. (2016) Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons. Cereb Cortex. PMID:27566978

Theme1Dot Kubota K, Chen J, Little MA (2016) Machine learning for large-scale wearable sensor data in Parkinson. disease: concepts, promises, pitfalls and futures. Movement Disorders Movement Disorders. PMID:27501026

Theme1Dot Lane JM, Vlasac I, Anderson SG, Kyle SD, Dixon WG, Bechtold DA, Gill S, Little MA, Luik A, Loudon A, Emsley R, Scheer FA, Lawlor DA, Redline S, Ray DW, Rutter MK, Saxena R. (2016) Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UKBiobank. Nature Communications, 7:10889. PMID:26955885

Theme1Dot Lawton M, Hu MT, Baig F, Ruffmann C, Barron E, Swallow DM, Malek N, Grosset KA, Bajaj N, Barker RA, Williams N, Burn DJ, Foltynie T, Morris HR, Wood NW, May MT, Grosset DG, Ben-Shlomo Y. (2016) Equating scores of the University of Pennsylvania Smell Identification Test and Sniffin' Sticks test in patients with Parkinson's disease. Parkinsonism Relat Disord. S1353-8020(16)30381-9. PMID:27729202

Theme1Dot Malek N, Lawton MA, Swallow DM, Grosset KA, Marrinan SL, Bajaj N, Barker RA, Burn DJ, Hardy J, Morris HR, Williams NM, Wood N, Ben-Shlomo Y, Grosset DG; PRoBaND Clinical Consortium. (2016) Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson's disease. Mov Disord. PMID:27324570

Theme1Dot Miller KL, Alfaro-Almagro F, Bangerter NK, Thomas DL, Yacoub E, Xu J, Bartsch AJ, Jbabdi S, Sotiropoulos SN, Andersson JLR, Griffanti L, Douaud G, Okell TW, Weale P, Dragonu I, Garratt S, Hudson S, Collins R, Jenkinson M, Matthews PM & Smith SM (2016) Multimodal population brain imaging in the UK Biobank prospective epidemiological study. Nature Neuroscience. doi.10.1038/nn.4393

Theme1Dot Muhammed K, Manohar S, Ben Yehuda M, Chong TT, Tofaris G, Lennox G, Bogdanovic M, Hu M, Husain M. (2016) Reward sensitivity deficits modulated by dopamine are associated with apathy in Parkinson's disease. Brain. PMID:27452600

Theme1Dot Panouillères MT, Tofaris GK, Brown P, Jenkinson N. (2016) Intact Acquisition and Short-Term Retention of Non-Motor Procedural Learning in Parkinson's Disease. PLOS ONE. 11(2):e0149224. PMID: 26906905

Theme1Dot Y.P. Raykov, A. Boukouvalas, F. Baig, M.A. Little. (2016) What to do when K-means clustering fails: a simple yet principled alternative algorithm
PLoS Onedoi.org/10.1371/journal.pone.0162259

Theme1Dot Rolinski M, Griffanti L, Piccini P, Roussakis AA, Szewczyk-Krolikowski K, Menke RA, Quinnell T, Zaiwalla Z, Klein JC, Mackay CE, Hu MT. (2016) Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson's disease. Brain. PMID: 27297241

Theme1Dot Ruffmann C, Parkkinen L. (2016) Gut Feelings About α-Synuclein in Gastrointestinal Biopsies: Biomarker in the Making? Movement Disorders. 31(2):193-202. PMID: 26799450.

Theme1Dot Silva de Lima AL, Hahn T, de Vries NM, Cohen E, Bataille L, Little MA, Baldus H, Bloem BR, Faber MJ. (2016) Large-Scale Wearable Sensor Deployment in Parkinson's Patients: The Parkinson@Home Study Protocol. JMIR Res Protoc. 5(3):e172. PMID:27565186

Theme3Dot Sloan M, Alegre-Abarrategui J, Potgieter D, Kaufmann AK, Exley R, Deltheil T, Threlfell S, Connor-Robson N, Brimblecombe K, Wallings R, Cioroch M, Bannerman DM, Bolam JP, Magill PJ, Cragg SJ, Dodson PD, Wade-Martins R (2016)LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function. Human Molecular Genetics. 25(5):951-63. PMID: 26744332

Theme1Dot Swallow DM, Lawton MA, Grosset KA, Malek N, Klein J, Baig F, Ruffmann C, Bajaj NP, Barker RA, Ben-Shlomo Y, Burn DJ, Foltynie T, Morris HR, Williams N, Wood NW, Hu MT, Grosset DG. (2016) Statins are underused in recent-onset Parkinson's disease with increased vascular risk: findings from the UK Tracking Parkinson's and Oxford Parkinson's Disease Centre (OPDC) discovery cohorts. J Neurol Neurosurg Psychiatry. 87(11):1183-1190. PMID:27671901

Theme1Dot Tofaris GK, Goedert M, Spillantini MG. (2016) The Transcellular Propagation and Intracellular Trafficking of α-Synuclein. Cold Spring Harb Perspect Med. pii: a024380. PMID:27920026

Theme2DotVazquez-Arango P, Vowles J, Browne C, Hartfield E, Fernandes HJ, Mandefro B, Sareen D, James W, Wade-Martins R, Cowley SA, Murphy S, O'Reilly D. (2016) Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease. Nucleic Acids Res.  pii: gkw711. PMID:27536002

2015

3 themes

Theme3Dot Abdi A, Mallet N, Mohamed FY, Sharott A, Dodson PD, Nakamura KC, Suri S, Avery S V., Larvin JT, Garas FN, Garas SN, Vinciati F, Morin S, Bezard E, Baufreton J, Magill PJ. (2015) Prototypic and Arkypallidal Neurons in the Dopamine-Intact External Globus Pallidus.  J Neurosci 35:6667–6688. PMID: 25926446

Theme1Dot Antoniades CA, Demeyere N, Kennard C, Humphreys GW, Hu MT. (2015) Antisaccades and executive dysfunction in early drug-naive Parkinson's disease: The discovery study. Mov Disord. 30(6):843-7. PMID: 25600361

Theme1Dot Baig F, Lawton M, Rolinski M, Ruffmann C, Nithi K, Evetts SG, Fernandes HR, Ben-Shlomo Y, Hu MT. (2015) Delineating Non-Motor Symptoms in Early Parkinson’s Disease and First Degree Relatives. Mov Disord. 30(13):1759-66. PMID:26179331

Theme3Dot Brimblecombe KR, Gracie CJ, Platt NJ, Cragg SJ (2015) Gating of dopamine transmission by calcium and axonal N, Q, T and L-type voltage-gated calcium channels differs between striatal domains. J Physiol. 593: 929-946. PMID: 25533038

Theme1Dot Chong T.T, Bonnelle V, Manohar S, Veromann K.R, Muhammed K, Tofaris G.K, Hu MT, Husain M. (2015) Dopamine enhances willingness to exert effort for reward in Parkinson’s disease. Cortex, 69:40-46. PMID: 25967086

Theme3Dot Dodson PD, Larvin JT, Duffell JM, Garas FN, Doig NM, Kessaris N, Duguid IC, Bogacz R, Butt SJ, Magill PJ. (2015) Distinct developmental origins manifest in the specialized encoding of movement by adult neurons of the external globus pallidus. Neuron. 86(2):501-13. PMID: 25843402

Theme1Dot Griffanti L, Rolinski M, Szewczyk-Krolikowski K, Menke RA, Filippini N, Zamboni G, Jenkinson M, Hu MT, Mackay CE. (2015) Challenges in the reproducibility of clinical studies with resting state fMRI: An example in early Parkinson's disease. Neuroimage. 124(Pt A):704-13. PMID:26386348

Theme1Dot Guerreiro REscott-Price VDarwent LParkkinen L, Ansorge OHernandez DGNalls MAClark LHonig LMarder Kvan der Flier WHolstege HLouwersheimer ELemstra AScheltens PRogaeva ESt George-Hyslop PLondos EZetterberg HOrtega-Cubero SPastor PFerman TJGraff-Radford NRRoss OABarber IBraae ABrown KMorgan KMaetzler WBerg DTroakes CAl-Sarraj SLashley T,Compta YRevesz TLees ACairns NJHalliday GMMann DPickering-Brown SPowell JLunnon KLupton MKInternational Parkinson's Disease Genomics Consortium (IPDGC)Dickson DHardy JSingleton ABras J. (2015) Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases. Neurobiology of Aging. 38:214.e7-10. PMID:26643944

Theme3Dot Hunn BHM, Cragg SJ, Bolam JP, Spillantini MG, Wade-Martins R (2015). Impaired intracellular trafficking defines early Parkinson’s disease. Trends Neurosci. 38:178-188. PMID: 2563977

Theme2Dot Keane HRyan BJ, Jackson B, Whitmore A, Wade-Martins R (2015). Protein-protein interaction networks identify targets which rescue the MPP(+) cellular model of Parkinson's disease. Scientific Reports. 5:17004. PMID:26608097

Theme3Dot Kosillo P, Brimblecombe K, Threlfell S, Cragg SJ (2015). Coupling optogenetics with voltammetry. In: Compendium of In Vivo Monitoring in Real-Time Molecular Neuroscience: Volume 1 - Fundamentals and Applications (Eds GS Wilson, AC Michael), World Scientific Publishing Co., Singapore, 2014, Ch 9, pp 201-223,

Theme1Dot Lawton M, Baig F, Rolinski M, Ruffman C, Nithi K, May MT, Ben-Shlomo Y, Hu MT (2015) Parkinson's Disease Subtypes in the Oxford Parkinson Disease Centre (OPDC) Discovery Cohort. Journal of Parkinson's Disease 5, p269-279. PMID:26405788

Theme3Dot Pristerà A, Lin W, Kaufmann A-K, Brimblecombe KR, Threlfell S, Dodson PD, Magill PJ, Fernandes C, Cragg SJ, and Ang S-L (2015) Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice. PNAS, 112(35):E4929-38. PMID 26283356

Theme1DotTheme2Dot Roberts  RF, Wade-Martins R, Alegre-Abarrategui J (2015) Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain. Brain, 138(Pt 6):1642-57. PMID:25732184

Theme1Dot Rolinski M, Griffanti L, Szewczyk-Krolikowski K, Menke R, Wilcock G, Filippini N, Zamboni G, Hu MT, Mackay CE (2015) Aberrant functional connectivity within the basal ganglia of patients with Parkinson's disease. NeuroImage: Clinical, 8: 126-132. PMID:26106536

Theme1Dot Rolinski MZokaei NBaig FGiehl KQuinnell TZaiwalla ZMackay CEHusain MHu MT (2015) Visual short-term memory deficits in REM sleep behaviour disorder mirror those in Parkinson’s disease. Brain. 139(Pt 1):47-53. PMID:26582557

Theme2Dot Ryan BJ, Crabtree MJ, Channon KM and Wade-Martins R (2015) Letter to editor: Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers. Brain. 138(Pt 5):e348. PMID: 25398233

Theme2Dot Ryan BJ, Hoek S, Fon EA, Wade-Martins R. (2015) Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease. Trends Biochem Sci. 40(4): 200–210. PMID:25757399

Theme2Dot Silva AM, Brown JM, Buckle VJ, Wade-Martins R and Lufino MMP (2015) Expanded GAA repeats impair FXN gene expression and reposition the FXN locus to the nuclear lamina in single cells. Human Molecular Genetics; 24(12):3457-71. PMID: 25814655

Theme1Dot Stephenson D, Hu MT, Romero K, Breen K, Burn D, Ben-Shlomo Y, Bhattaram A, Isaac M, Venuto C, Kubota K, Little MA, Friend S, Lovestone S, Morris HR, Grosset D, Sutherland M, Gallacher J, Williams-Gray C, Bain LJ, Avilés E, Marek K, Toga AW, Stark Y, Forrest Gordon M, Ford S. (2015) Precompetitive Data Sharing as a Catalyst to Address Unmet Needs in Parkinson's Disease. Journal of Parkinson's Disease 5(3):581-94 PMID:26406139

Theme1Dot Tomlinson PR, Zheng Y, Fischer R, Heidasch R, Gardiner C, Evetts S, Hu M, Wade-Martins R, Turner M.R., Morris J, Talbot K, Kessler KM and Tofaris GK (2015) Identification of distinct circulating exosomes in Parkinson's disease. Annals of Clinical and Translational Neurology.
2(4):353-61. PMID:25909081

Theme1Dot Vaikath NN, Majbour NK, Paleologou KE, Ardah MT, van  Dam E, van  de  Berg WDJ, Forrest SL, Parkkinen L, Gai W-P, Hattori N, Takanashi,  Lee S-J, Mann DMA, Imai Y, Halliday GM, Li J-Y, El-Agnaf OMA (2015) Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology. Neurobiology of Diseases. 79:81-99. PMID:25937088

2014

3 themes

Theme1Dot Alafuzoff I, Parkkinen L. (2014) Staged pathology in Parkinson's Disease. Parkinsonism & Related Disorders. 20(S1): S57-61. PMID:24262190

Theme2Dot Badger JL, Cordero-Llana O, Hartfield EM, Wade-Martins R. (2014) Parkinson's Disease in a dish - using stem cells as a molecular tool. Neuropharmacology. 76(A) 88-96. PMID:24035919

Theme1Dot Bras J, Guerreiro R, Darwent L, Parkkinen L, Ansorge O, Escott-Price V, Hernandez  DG, Nalls M, Clark L, Honig L, Marder K, van der Flier W, Lemstra E, Scheltens P, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Ortega-Cubero S, Pastor P, Ferman TJ, Graff-Radford NR, Ross OA, Barber I, Braae A, Brown K, Morgan K, Maetzler W, Berg D, Troakes C, Al-Sarraj S, Lashley T, ComptaY, Revesz T, Lees A, Cairns N, Halliday GM, Mann D, Pickering-Brown S, Dickson D, Singleton S, Hardy J (2014) Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of Dementia with Lewy Bodies. Hum Mol Genet. 23(23):6139-46. PMID:24973356

Theme1Dot Compta Y, Parkkinen L, Kempster P, Selikhova M, Lashley T, Holton JL, Lees AJ, Revesz T. (2014) The Significance of α-Synuclein, Amyloid-β and Tau Pathologies in Parkinson's Disease Progression and Related Dementia. Neurodegener Dis. 13(2-3) 154-6. PMID:24028925

Theme1Dot Davies SE, Hallett PJ, Moens T, Smith G, Mangano E, Kim HT, Goldberg AL, Liu JL, Isacson O, Tofaris GK. (2014) Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease. Neurobiol Dis. 64:79-87. PMID:24388974

Theme2Dot Hartfield, E.M., Yamasaki-Mann, M., Ribeiro Fernandes, H.J., Vowles, J., James, W.S., Cowley, S.A. and Wade-Martins, R. (2014) Physiological characterisation of human iPS-derived dopaminergic neurons. PLoS ONE 9(2): e87388 PMID:24586273

Theme3Dot Henny P, Brown MT, Micklem BR, Magill PJ, Bolam JP. (2014) Stereological and ultrastructural quantification of the afferent connectome of individual neurons. Brain Struct Funct. 219(2):631-40 PMID: 23479177

Theme1Dot Hu M, Szewczyk-Krolikowski K, Tomlinson P, Nithi K, Rolinski M, Murray C, Talbot K, Ebmeier K, Ben-Shlomo Y. (2014) Predictors of cognitive impairment in an early stage Parkinson’s disease cohort.  Movement Disorders. 29(3):351-9 PMID:24395708

Theme3Dot Martinez-Gonzalez C, van Andel J, Bolam JP, Mena-Segovia J. (2014) Divergent motor projections from the pedunculopontine nucleus are differentially regulated in Parkinsonism. Brain Struct Funct. 219(4):1451-62. PMID:23708060

Theme1Dot Menke RA, Szewczyk-Krolikowski K, Jbabdi S, Jenkinson M, Talbot K, Mackay CE, Hu M. (2014) Comprehensive morphometry of subcortical grey matter structures in early-stage Parkinson's disease. Hum Brain Mapp. 35(4): 1681-90. PMID:23861334

Theme3Dot Nevado-Holgado, A.J., Mallet, N., Magill, P.J., Bogacz, R. (2014) Effective connectivity of the subthalamic nucleus-globus pallidus network during Parkinsonian oscillations. Journal of Physiology. 592(Pt 7):1429-55. PMID:  24344162 See comment (Slaves to the rhythm: coupling of the subthalamic nucleus–globus pallidus network in Parkinsonian oscillations)

Theme1Dot Parkkinen L, Lees AJ. (2014) Is levodopa toxic? Insights from pathological studies. Focus on Parkinson’s Disease. 24(1): 16 – 20.

Theme2Dot Roberts TC, Morris KV, Wood MJ. (2014) The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease.
Philos Trans R Soc Lond B Biol Sci. 369(1652). pii: 20130507. PMID: 25135968

Theme1Dot Rolinski M, Szewczyk-Krolikowski K, Tomlinson PR, Nithi K, Talbot K, Ben-Shlomo Y, Hu MT. (2014) REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease. J Neurol Neurosurg Psychiatry. 85(5):560-6. PMID:24187013

Theme2Dot Ryan BJ, Lourenço-Venda L, Crabtree MJ, Hale AB, Channon KM and Wade-Martins R. (2014) α-synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of PD. Free Radical Biology and Medicine 67:58-68. PMID:24148766

Theme1Dot Szewczyk-Krolikowski K, Menke RAL, Rolinski M, Duff E, Salimi-Khorshidi G, Filippini N, Zamboni G, Hu MTM and Mackay CE (2014) Functional connectivity in the basal ganglia network differentiates PD patients from controls. Neurology, 83(3): 208–214. PMID:24920856

Theme1Dot Szewczyk-Krolikowski K, Tomlinson P, Nithi K, Wade-Martins, R., Talbot K, Ben-Shlomo Y and Hu M (2014) The influence of age and gender on motor and non-motor features of early Parkinson's disease: Initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort.  Parkinsonism & Related Disorders 20(1):99-105. PMID:24183678

Theme3Dot Taylor TN, Potgieter D, Anwar S, Senior SL, Janezic S, Threlfell S, Parkkinen L, Livieratos A, Oliver PL, Jennings KA, Davies KE, Ansorge O, Bannerman DM, Cragg SJ, Wade-Martins R. (2014) Region-specific deficits in dopaminergic, but not norepinephrinergic, signaling in a novel A30P-synuclein BAC transgenic mouse. Neurobiol Dis. 62(100): 193–207. PMID:24121116

Theme1Dot Xu Q, Evetts S, Hu M, Talbot KWade-Martins R, Davis JJ (2014). An impedimetric assay of α-synuclein autoantibodies in early stage Parkinson's disease. RSC Advances 4(102): 58773-58777. DOI: 10.1039/C4RA10100F

Theme1Dot Zokaei N, McNeill A, Proukakis C, Beavan M, Jarman P, Korlipara P, Hughes D, Mehta A, Hu MT, Schapira AH, Husain M. (2014) Visual short-term memory deficits associated with GBA mutation and Parkinson's disease. Brain, 137(8): 2303-11. PMID:24919969

2013

3 themes
Theme2Dot Beevers, J.E., Caffrey, T.M., Wade-Martins, R. (2013) Induced pluripotent stem-cell (iPSC)-derived dopaminergic models of Parkinson's disease. Biochem. Soc. Trans. 41(6). PMID:24256244

Theme1Dot Douaud G, Menke RA, Gass A, Monsch AU, Rao A, Whitcher B, Zamboni G, Matthews PM, Sollberger M, Smith S. (2013) Brain microstructure reveals early abnormalities more than two years prior to clinical progression from mild cognitive impairment to Alzheimer's disease. J Neurosci. 30;33(5):2147-55. PMID: 23365250

Theme2Dot Heman-Ackah SM, Hallegger M, Rao MS, Wood MJ. (2013) RISC in PD: the impact of microRNAs in Parkinson's disease cellular and molecular pathogenesis. Front Mol Neurosci. 20;6:40. PMID:24312000

Theme3Dot Janezic S, Threlfell S, Dodson PD, Dowie MJ, Taylor TN, Potgieter D, Parkkinen L, Senior SL, Anwar S, Ryan B, Deltheil T, Kosillo P, Cioroch M, Wagner K, Ansorge O, Bannerman DM, Bolam JP, Magill PJ, Cragg SJ, Wade-Martins R. (2013) Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson’s model. Proc Natl Acad Sci USA. 110(24) PMID:24082145

Theme2Dot Lufino MM, Silva AM, Németh AH, Alegre-Abarrategui J, Russell AJ, Wade-Martins R. (2013) A GAA repeat expansion reporter model of Friedreich's ataxia recapitulates the genomic context and allows rapid screening of therapeutic compounds. Hum Mol Genet. 22(25):5173-87. PMID: 23943791

Theme2Dot Ryan BJ, Lourenço-Venda L, Crabtree MJ, Hale AB, Channon KM and Wade-Martins R (2013) α-synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of PD. Free Radic Biol Med. 67C:58-68. PMID: 24148766

Theme2Dot Thomas M, Alegre-Abarrategui J, Wade-Martins R. (2013) RNA dysfunction and aggrephagy at the centre of an amyotrophic lateral sclerosis/frontotemporal dementia disease continuum. Brain. 136(Pt 5): 1345-60. PMID:23474849

Theme3Dot Threlfell S, West AR. (2013) Review: Modulation of striatal neuron activity by cyclic nucleotide signaling and phosphodiesterase inhibition. Basal Ganglia. 3(3):137-146. PMID: 24490129

Theme2Dot van Wilgenburg B, Browne C, Vowles J, Cowley SA. (2013) Efficient, Long Term Production of Monocyte-Derived Macrophages from Human Pluripotent Stem Cells under Partly-Defined and Fully-Defined Conditions. PLoS One. 8(8):e71098. PMID:23951090

2012

3 themes

Theme3Dot Bolam, J.P. and Pissadaki, E. (2012) Living on the edge with too many mouths to feed: why dopamine neurons die. Movement Disorders. 27(12):1478-83. PMID:23008164

Theme2Dot Hartfield, E. M., Fernandes, H. J., Vowles, J., Cowley, S. A., and Wade-Martins, R. (2012). Cellular reprogramming: a new approach to modelling parkinson's disease. Biochemical Society Transactions, 40(5):1152-1157. PMID:2298888

Theme1Dot Menke RA, Abraham I, Thiel CS, Filippini N, Knight S, Talbot K, Turner MR. (2012) Fractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis. Arch Neurol. 69(11):1493-9. PMID: 22910997

Theme2Dot Sibley CR, Seow Y, Curtis H, Weinberg MS and Wood MJA. (2012) Silencing of Parkinson's disease associated genes with artificial mirtron mimics of miR-1224. Nucleic Acids Res. 40(19):9863-75. PMID: 22848108

Theme3Dot Sloan M, Alegre-Abarrategui J, Wade-Martins R. (2012) Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models. Biochem Soc Trans. 2012 40:1080-5. PMID: 22988869

Theme3Dot Threlfell S, Lalic T, Platt NJ, Jennings KA, Deisseroth K, Cragg SJ. (2012) Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons. Neuron 75:58-64. PMID:22794260 (See Preview by Surmeier and Graybiel (2012) Neuron 75:1-3)

Theme1Dot Tofaris GK. (2012) Lysosome-dependent pathways as a unifying theme in Parkinson’s disease. Mov. Disorders Sep 15;27(11):1364-9. PMID:22927213

2011

3 themes

Theme3Dot Anwar S, Peters O, Millership S, Ninkina N, Doig N, Connor-Robson N, Threlfell S, Kooner G, Deacon RM, Bannerman DM, Bolam JP, Chandra SS, Cragg SJ, Wade-Martins R, Buchman VL. (2011) Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family. J Neurosci. 31(20):7264-74. PMID:21593311

Theme1Dot Compta Y*, Parkkinen L*, O'Sullivan SS, Vandrovcova J, Holton JL, Collins C, Lashley T, Kallis C, Williams DR, de Silva R, Lees AJ, Revesz T (*authors contributed equally) (2011)  Lewy- and Alzheimer type pathologies in Parkinson's disease dementia: which is more important? Brain. 134:1493-505. PMID: 21596773

Theme1Dot Gallagher DA, Parkkinen L, O'Sullivan SS, Spratt A, Shah A, Davey CC, Bremner FD, Revesz T, Williams DR, Lees AJ, Schrag A. (2011) Testing an aetiological model of visual hallucinations in Parkinson's disease. Brain. 134(Pt 11):3299-309. PMID: 21921019

Theme1Dot Hu MT, Butterworth R, Kumar V, Cooper J, Jones E, Catterall L, Ben-Shlomo Y (2011) How common and what are the determinants of sub-optimal care for Parkinson's disease patients: the Milton Keynes community study. Parkinsonism Relat Disord. 17(3):177-81. PMID:21239210

Theme1Dot Hu M, Cooper J, Beamish R, Jones E, Butterworth R, Catterall L, Ben-Shlomo Y. (2011) How well do we recognise non-motor symptoms in a British Parkinson's disease population? J Neurol. 258(8):1513-7. PMID: 21394490

Theme1Dot Parkkinen L, O'Sullivan S, Kuoppamaki M, Holton JL, Revesz T, Lees AJ. (2011) Does levodopa accelerate the pathologic process in Parkinson disease brain? Neurology. 77(15):1420-6. PMID:21917769

Theme1Dot Parkkinen L, O’Sullivan S, Collins C, Petrie A, Holton JL, Revesz T, Lees AJ. (2011) Disentangling the relationship between Lewy bodies and nigral neuronal loss in Parkinson’s disease. Journal of Parkinson’s Disease (3):277-86. PMID:23939308

Theme3Dot Rice ME, Patel JC, Cragg SJ (2011). Dopamine release in the basal ganglia. Neuroscience, 198:112-37. PMID:21939738

Theme2Dot Sibley CR, Wood MJA. (2011) Identification of allele-specific RNAi effectors targeting genetic forms of Parkinson’s disease. PLoS One 6(10):e26194. PMID:22031823

Theme3Dot Threlfell S, Cragg SJ (2011). Striatal acetylcholine-dopamine crosstalk and the dorsal-ventral divide. In: Dopamine-glutamate interactions in the basal ganglia (Ed. S. Jones), Routledge (Taylor and Francis Group), London, Chapter 6, pp 119-138

2010

Theme3Dot Lourenço-Venda L, Cragg SJ, Buchman VL, Wade-Martins, R. (2010). α-Synuclein and dopamine at the crossroads of Parkinson’s disease, Trends Neurosci, 33:559-568. PubMed ID: 20961626