The Oxford Parkinson's Disease Centre (OPDC) is a unique multidisciplinary research centre at the University of Oxford supported by Parkinson’s UK with funds from The Monument Trust, one of the Sainsbury Family Charitable Trusts.
Established in February 2010, the Oxford Parkinson’s Disease Centre (OPDC) brings together internationally-renowned scientists who work on the genetics of Parkinson’s, the generation of cell and animal models, and the wiring of brain circuits which control movement, with clinical experts in the diagnosis and treatment of Parkinson’s.
Our programme targets the molecular pathways to Parkinson’s in order to:
Arora S, Baig F, Lo C, Barber TR, Lawton MA, Zhan A, Rolinski M, Ruffmann C, Klein JC, Rumbold J, Louvel A, Zaiwalla Z, Lennox G, Quinnell T, Dennis G, Wade-Martins R, Ben-Shlomo Y, Little MA, Hu MT. (2018) Smartphone motor testing to distinguish idiopathic REM sleep behavior disorder, controls, and PD. Neurology. PMID:30232246
Barber TR, Griffanti L, Muhammed K, Drew DS, Bradley KM, McGowan DR, Crabbe M, Lo C, Mackay CE, Husain M, Hu MT, Klein JC; Oxford Parkinson's Disease Centre. (2018) Apathy in rapid eye movement sleep behaviour disorder is associated with serotonin depletion in the dorsal raphe nucleus. Brain. PMID:30212839
Researchers at OPDC are embarking on a new five-year study looking at the links between a condition known as Rapid Eye Movement Sleep Behaviour Disorder (RBD) and Parkinson’s. Funded by the NIHR Oxford Biomedical Research Centre. The study seeks to improve the remote diagnosis and monitoring of sleep problems at home and is currently looking for people with Parkinson's and RBD to take part. RBD is a sleep problem where the switch that ...
Work with OPDC from a DPhil project supported by the Oxford branch of Parkinson’s UK has been published in the journal Stem Cell Reports. The project, carried out under the supervision of OPDC’s Richard Wade-Martins focussed on the MAPT (microtubule-associated protein tau) gene, which provides the code for a set of six proteins called ‘tau’, and each of these six tau proteins is made from a different messenger RNA transcript made from the MAPT ...
Last year, we published a paper showing that apathy is very common in people with idiopathic REM sleep behaviour disorder (RBD), and we have now followed this up with a brain imaging study that sheds light on why this is. Apathy is a condition where people feel a sense of indifference to doing activities or being with other people. It is very common in people with Parkinson’s and can have a severe effect on their lives and those of their ...
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Using transcriptomics to understand neurodegenerative disorders MRC Post-doctoral Fellow UCL Institute of Neurology As an MBPhD graduate (Cambridge University & University College London) and Academic Clinical Fellow in Neurology (London Deanery), I have been lucky enough to receive training in basic research as well as clinical medicine. I have thoroughly enjoyed both and am committed to pursuing a joint clinical and research career in ...
Challenges and Opportunities of Translational Neurogenomics Dr. Scholz is a Neurologist and Neurogeneticist specialized in movement disorders. She received her medical degree from the Medical University Innsbruck, Austria. Following graduation, she was a post-doctoral fellow at the Laboratory of Neurogenetics (NIA) under the supervision of Drs. Andrew Singleton and John Hardy. She obtained a Ph.D. in Neurogenomics from the University ...
© 2018 Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, South Parks Road, Oxford, OX1 3QX
Tel: 01865 282358 | Enquiries: opdc.administrator@dpag.ox.ac.uk
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