The Oxford Parkinson's Disease Centre (OPDC) is a unique multidisciplinary research centre at the University of Oxford supported by Parkinson’s UK with funds from The Monument Trust, one of the Sainsbury Family Charitable Trusts.
Established in February 2010, the Oxford Parkinson’s Disease Centre (OPDC) brings together internationally-renowned scientists who work on the genetics of Parkinson’s, the generation of cell and animal models, and the wiring of brain circuits which control movement, with clinical experts in the diagnosis and treatment of Parkinson’s.
Our programme targets the molecular pathways to Parkinson’s in order to:
Arora S, Baig F, Lo C, Barber TR, Lawton MA, Zhan A, Rolinski M, Ruffmann C, Klein JC, Rumbold J, Louvel A, Zaiwalla Z, Lennox G, Quinnell T, Dennis G, Wade-Martins R, Ben-Shlomo Y, Little MA, Hu MT. (2018) Smartphone motor testing to distinguish idiopathic REM sleep behavior disorder, controls, and PD. Neurology. PMID:30232246
Barber TR, Griffanti L, Muhammed K, Drew DS, Bradley KM, McGowan DR, Crabbe M, Lo C, Mackay CE, Husain M, Hu MT, Klein JC; Oxford Parkinson's Disease Centre. (2018) Apathy in rapid eye movement sleep behaviour disorder is associated with serotonin depletion in the dorsal raphe nucleus. Brain. PMID:30212839
Parkinson’s researchers Dayne Beccano-Kelly, Siv Vingill and Nora Bengoa-Vergniory, along with OPDC administrator Melanie Witt travelled to the Royal Oak, Goodworth Clatford in Andover for a quiz night in aid of Parkinson’s research. During the night, held on Wednesday 12 December, OPDC supporters Bobbie Coelho, Mary Doherty and Dawn Huntly presented a cheque for £1,500 to support Parkinson’s research. The funds have been raised by a number ...
The videos focus on two of our projects to use new technology to better understand the progression of Parkinson's. The first highlights our sleep study which aims to make it possible to monitor sleep in the home using wearable devices. The second features our smartphone app which monitors different motor symptoms of Parkinson's to improve our understanding of Parkinson's and help us improve treatments.
Researchers at OPDC are embarking on a new five-year study looking at the links between a condition known as Rapid Eye Movement Sleep Behaviour Disorder (RBD) and Parkinson’s. Funded by the NIHR Oxford Biomedical Research Centre. The study seeks to improve the remote diagnosis and monitoring of sleep problems at home and is currently looking for people with Parkinson's and RBD to take part. RBD is a sleep problem where the switch that ...Click here to sign up to the OPDC News Mailing list
Molecular pathways to Parkinson's disease: more than neurons? Dr. Elisa Greggio is a molecular physiologist in the Department of Biology at the University of Padova, Italy. RESEARCH INTERESTS: Genetic forms of dominant Parkinson's.Mitochondrial function, axonal transport and cellular pathways in Parkinson's.Biochemical properties of Leucine-rich repeat kinase 2 (LRRK2).Oxidative stress in ...
LRRK2 Mediated Cellular Function from Vesicular Trafficking to Gene Expression. My research has focused on two main aspects of neurobiology, the pathogenesis of Parkinson’s and trapping and accumulation of inhibitory receptors at synapses. In my laboratory, we employ cell biological, biochemistry and proteomic techniques in an effort to: i) discover how pathogenic mutations in PARK genes lead to neuronal death, ii) uncover new leads for ...