Professor Kirsten Harvey


Wednesday 27th March 2019

Professor of Molecular Neuroscience and Cell Biology
UCL School of Pharmacy

LRRK2 Mediated Cellular Function from Vesicular Trafficking to Gene Expression.

My research has focused on two main aspects of neurobiology, the pathogenesis of Parkinson’s and trapping and accumulation of inhibitory receptors at synapses.

In my laboratory, we employ cell biological, biochemistry and proteomic techniques in an effort to:

i) discover how pathogenic mutations in PARK genes lead to neuronal death,

ii) uncover new leads for genetic analysis, and

iii) identify new therapeutic targets for disease modifying treatment.

My current research focus is on the physiological and pathological role of the Parkinson’s protein LRRK2 in Wnt signalling and cytoskeletal function. In addition, I continue to research the role of proteins important for receptor clustering such as gephyrin and collybistin in inhibitory receptor clustering and intellectual disability.