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This study, supported by the NIHR Oxford Biomedical Research Centre (BRC) and funded by the Monument Trust Discovery Award from Parkinson's UK, has the potential to foster a more personalised approach to the treatment of Parkinson’s and allow clinicians to target interventions to those individuals most likely to benefit. The smartphone test guides users through seven tasks assessing voice, balance, walking, reaction time, finger tapping, rest ...
Our new paper is one of the first to report genome-wide transcriptomic RNA-Seq profiling of stem cell-derived astrocytes from people with Parkinson's & healthy controls. In the brain, Parkinson’s is characterized by damage to dopaminergic neurons and accumulation of clumps of the protein α-synuclein. However, growing evidence indicates that other types of cells, including astrocytes, may contribute significantly to how Parkinson's ...
OPDC Career Development Fellows Natalie Connor-Robson, Dayne Becanno-Kelly and administrator Melanie Witt visited a local Woodcraft Folk Elfins group in Dementia Action Week this May to talk about our work to better understand the brain. The group of 6-9 year olds listened carefully as Dayne and Natalie introduced ideas of how the brain works, how sometimes things can go wrong in conditions like Parkinson's, and how we are trying to better ...
OPDC's Wade-Martins Group has identified how the dysfunction of a key protein, LRRK2, causes the neurons affected in Parkinson's to lose their ability to effectively clear out cell components that have been damaged. This discovery has enabled the team to find a new way to target and correct this issue, paving the way for a potential new clinical treatment. Wade-Martins study uncovers a new way to target and treat the leading genetic ...
This week Oxford University's Department of Physiology, Anatomy and Genetics is marking World Parkinson's Day, which takes place on Thursday 11 April 2019, with an inside look into the Wade-Martins Laboratory. The Wade-Martins Group conducts critical research into several neurodegenerative diseases, and makes up part of the OPDC with its work into Parkinson's, with the aim to understand the molecular mechanisms of these disorders and help ...
A new study from OPDC Career Development Fellow Natalie Connor-Robson investigates how mutations in the gene LRRK2, which are known to cause Parkinson’s, effect normal cell function. We generated dopaminergic neurons, the cells that are affected in Parkinson’s, from stem cells reprogrammed using skin samples donated by people with Parkinson’s who carry LRRK2 mutations. These neurons were used for in depth analysis which showed the most altered ...
The videos focus on two of our projects to use new technology to better understand the progression of Parkinson's. The first highlights our sleep study which aims to make it possible to monitor sleep in the home using wearable devices. The second features our smartphone app which monitors different motor symptoms of Parkinson's to improve our understanding of Parkinson's and help us improve treatments.
In a new study from OPDC researchers we generated dopaminergic neurons, the cells that are affected in Parkinson’s, from stem cells reprogrammed using skin samples donated by people with Parkinson’s who have changes in the alpha-synuclein gene (alpha-synuclein mutation and triplication). We observed that cells produced from these people with Parkinson’s accumulated detrimental alpha-synuclein species in the cells. The cells also showed problems ...
Parkinson’s researchers Dayne Beccano-Kelly, Siv Vingill and Nora Bengoa-Vergniory, along with OPDC administrator Melanie Witt travelled to the Royal Oak, Goodworth Clatford in Andover for a quiz night in aid of Parkinson’s research. During the night, held on Wednesday 12 December, OPDC supporters Bobbie Coelho, Mary Doherty and Dawn Huntly presented a cheque for £1,500 to support Parkinson’s research. The funds have been raised by a number ...
Researchers at OPDC are embarking on a new five-year study looking at the links between a condition known as Rapid Eye Movement Sleep Behaviour Disorder (RBD) and Parkinson’s. Funded by the NIHR Oxford Biomedical Research Centre. The study seeks to improve the remote diagnosis and monitoring of sleep problems at home and is currently looking for people with Parkinson's and RBD to take part. RBD is a sleep problem where the switch that ...
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