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Research spotlight: I want to get high enough up the chain to pull others over the wall with me

Research spotlight: I want to get high enough up the chain to pull others over the wall with me

Posted 04/11/2019

    Continuing their series celebrating ‘amazing people at Oxford who you should know about’, the Central University's Science Blog talks to Dayne Beccano-Kelly, an electrophysiologist and Career Development Fellow in the Department of Physiology, Anatomy and Genetics, and part of the Oxford Parkinson’s Disease Centre.Read the Central University's Science Blog talks here: ...

Caution when looking at cell recycling in Parkinson’s

Caution when looking at cell recycling in Parkinson’s

Posted 31/10/2019

Researchers at the Oxford Parkinson’s Disease Centre have shown that cell recycling in Parkinson’s may play a more complex role than previously thought. These new results have been published in the journal of Cell Reports. Read the full story on the Parkinson's UK website.  

NIH-OxCam: a graduate student's journey to Oxford by Stewart Humble

NIH-OxCam: a graduate student's journey to Oxford by Stewart Humble

Posted 30/10/2019

Read about our DPhil student; Stewart Humble, who came to the Wade-Martins Lab from Louisiana State University Health Sciences Center in New Orleans as part of the National Institutes of Health Oxford-Cambridge Scholars Programme (NIH-OxCam). Here is his story giving an account of his research journey so far "NIH-OxCam: a graduate student's journey to Oxford" https://www.dpag.ox.ac.uk/news/nih-oxcam-a-graduate-students-journey-to-oxford  

Research Spotlight for Black History Month: Pavandeep Rai

Research Spotlight for Black History Month: Pavandeep Rai

Posted 30/10/2019

October is Black History Month, which is celebrated nationwide every year to recognise the contributions that people from BAME backgrounds have made to this country. As part of Black History Month, Pavandeep Rai, our Postdoctoral Research Scientist working in the OPDC gave an in depth interview about working at the forefront of an industry/academia collaborative project aimed at developing potential new drugs to treat ...

Smartphone test predicts how symptoms develop in Parkinson’s

Smartphone test predicts how symptoms develop in Parkinson’s

Posted 01/08/2019

This study, supported by the NIHR Oxford Biomedical Research Centre (BRC) and funded by the Monument Trust Discovery Award from Parkinson's UK, has the potential to foster a more personalised approach to the treatment of Parkinson’s and allow clinicians to target interventions to those individuals most likely to benefit. The smartphone test guides users through seven tasks assessing voice, balance, walking, reaction time, finger tapping, rest ...

New OPDC Research into the role of Astrocytes in Parkinson's Progression

New OPDC Research into the role of Astrocytes in Parkinson's Progression

Posted 04/06/2019

Our new paper is one of the first to report genome-wide transcriptomic RNA-Seq profiling of stem cell-derived astrocytes from people with Parkinson's & healthy controls. In the brain, Parkinson’s is characterized by damage to dopaminergic neurons and accumulation of clumps of the protein α-synuclein. However, growing evidence indicates that other types of cells, including astrocytes, may contribute significantly to how Parkinson's ...

OPDC visits local children's group for Dementia Awareness Week

OPDC visits local children's group for Dementia Awareness Week

Posted 21/05/2019

OPDC Career Development Fellows Natalie Connor-Robson, Dayne Becanno-Kelly and administrator Melanie Witt visited a local Woodcraft Folk Elfins group in Dementia Action Week this May to talk about our work to better understand the brain. The group of 6-9 year olds listened carefully as Dayne and Natalie introduced ideas of how the brain works, how sometimes things can go wrong in conditions like Parkinson's, and how we are trying to better ...

OPDC study uncovers a new way to target and treat the leading genetic contributor to Parkinson's

OPDC study uncovers a new way to target and treat the leading genetic contributor to Parkinson's

Posted 01/05/2019

OPDC's Wade-Martins Group has identified how the dysfunction of a key protein, LRRK2, causes the neurons affected in Parkinson's to lose their ability to effectively clear out cell components that have been damaged. This discovery has enabled the team to find a new way to target and correct this issue, paving the way for a potential new clinical treatment. Wade-Martins study uncovers a new way to target and treat the leading genetic ...

Inside the Wade-Martins lab

Inside the Wade-Martins lab

Posted 11/04/2019

This week Oxford University's Department of Physiology, Anatomy and Genetics is marking World Parkinson's Day, which takes place on Thursday 11 April 2019, with an inside look into the Wade-Martins Laboratory. The Wade-Martins Group conducts critical research into several neurodegenerative diseases, and makes up part of the OPDC with its work into Parkinson's, with the aim to understand the molecular mechanisms of these disorders and help ...

OPDC study finds mutations in the gene LRRK2 affect normal cell function.

OPDC study finds mutations in the gene LRRK2 affect normal cell function.

Posted 11/04/2019

A new study from OPDC Career Development Fellow Natalie Connor-Robson investigates how mutations in the gene LRRK2, which are known to cause Parkinson’s, effect normal cell function. We generated dopaminergic neurons, the cells that are affected in Parkinson’s, from stem cells reprogrammed using skin samples donated by people with Parkinson’s who carry LRRK2 mutations. These neurons were used for in depth analysis which showed the most altered ...