OPDC Publications

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3 themes

Theme2Dot Agarwal, D, Sandor, C, Volpato, V, Caffrey TM, Monzón-Sandoval J, Bowden R, Alegre-Abarrategui J, Wade-Martins R, Webber C (2020) A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders. Nat Commun 11, 4183 (2020). https://doi.org/10.1038/s41467-020-17876-0

Theme1Dot Auger SD, Kanavou S, Lawton M, Ben-Shlomo Y, Hu MT, Schrag AE, Morris HR, Grosset DG, Noyce AJ (2020). Testing Shortened Versions of Smell Tests to Screen for Hyposmia in Parkinson's Disease. Mov Disord Clin Pract. 2020;7(4):394-398. Published 2020 Mar 21. doi:10.1002/mdc3.12928

Theme1Dot Barber TAGriffanti L, Bradley KM, McGowan D, Lo C, Mackay CEHu MT, Klein JC (2020). Nigrosome 1 imaging in REM sleep behaviour disorder and its association with dopaminergic decline. Ann Clin Transl Neurol. 2020;7(1):26-35. doi: 10.1002/acn3.50962

Theme1Dot Bauermeister S, Orton C, Thompson S, Hu MT et al (2020). The Dementias Platform UK (DPUK) Data Portal. Eur J Epidemiol. 2020;35(6):601-611. doi:10.1007/s10654-020-00633-4

Theme1Dot Carling PJ, Mortiboys H, Green C, Mihaylov S, Sandor C,  Schwartzentruber A, Taylor, Wei W, Hastings C, Wong S, Lo CEvetts S, Clemmens HWyles MWillcox SPayne THughes R,   Ferraiuolo LWebber CHide WWade-Martins R, Talbot K, Hu MT, Bandmann O (2020). Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson's disease. Prog Neurobiol. 2020;187:101772. doi:10.1016/j.pneurobio.2020.101772

 Theme1Dot Del Din S, Yarnall AJ, Barber TRLo C, Crabbe M, Rolinski M, Baig F, Hu MT, Rochester L (2020). Continuous real-world gait monitoring in idiopathic REM sleep behaviour disorder. J Parkinsons Dis. 2020;10(1):283-299. doi: 10.3233/JPD-191773

Theme1Dot Drew DS, Muhammed K, Baig F, Kelly M, Okai D, Hu M, Manohar S, Husain M (2020). Dopamine and reward hypersensitivity in Parkinson's disease with impulse control disorder [published online ahead of print, 2020 Aug 6]. Brain. 2020;awaa198. doi:10.1093/brain/awaa198

Theme1Dot Griffanti LKlein JC, Szewczyk-Krolikowski K, Menke R, Rolinski M, Barber TR, Begeti F, Crabbe M, Rumbold JWade-Martins RHu MTMackay CE (2020). Cohort Profile: the Oxford Parkinson's Disease Centre Discovery Cohort magnetic resonance imaging sub-study (OPDC-MRI). BMJ Open. 2020;10(8):e034110. Published 2020 Aug 13. doi:10.1136/bmjopen-2019-034110

Theme1Dot Hu MT. Review: REM Sleep Behavior Disorder (RBD) (2020). Neurobiol Dis. 2020;143:104996. doi:10.1016/j.nbd.2020.104996

Theme1Dot Jiang C, Hopfner F, Katsikoudi A, Catli C, Evetts S, Huang Y, Wang H, Ryder JW, Deuschl G, Berg D, Borroni B, Hu MT, David JJ, Tofaris GK (2020). Serum neuronal exosomes predict and differentiate Parkinson's disease from atypical parkinsonism. J Neurol Neurosurg Psychiatry. 2020;91(7):720-729. doi:10.1136/jnnp-2019-322588 

Theme1Dot Kelly MJ, Baig F, Hu MT, Okai D (2020). Spectrum of impulse control behaviours in Parkinson's disease: pathophysiology and management. J Neurol Neurosurg Psychiatry. 2020;91(7):703-711. doi:10.1136/jnnp-2019-322453

Theme1Dot Kobylecki C, Carrasco R, Boca M, Lawton M, Chaudhuri KR, Hu MT, Grosset D, Silverdale MA (2020). The association between pain and impulse control behaviours in Parkinson’s disease. Parkinsonism Relat Disord. 2020;78:53-55. doi:10.1016/j.parkreldis.2020.07.005

Theme1Dot Lawton M, Baig F, Toulson G, Morovat A, Evetts SGBen-Shlomo YHu MT (2020). Blood biomarkers with Parkinson’s disease clusters and prognosis: the Oxford Discovery Cohort. Mov Disord. 2020;35(2):279-287. doi:10.1002/mds.27888

Theme1Dot Mackay CE, Szewczyk-Krolikowski K, Ben-Shlomo YHu M.Response: “first step” of biomarker development. Neurology 2020. https://n.neurology.org/content/response-first-step-biomarker-development

Theme1Dot Williams NM, Hubbard L, Sandor C, Webber C, Hendry H, Carroll C, Lawton M, Chaudhuri KR, Morris H, Hu MT, Grosset DG, Kobylecki C, Silverdale M (2020). Genome-Wide Association Study of Pain in Parkinson's Disease Implicates TRPM8 as a Risk Factor. Mov Disord. 2020;35(4):705-707. doi:10.1002/mds.28001



3 themes


Theme1Dot Bohnen NI, HuMT. Sleep disturbance as potential risk and progression factor for Parkinson’s disease. J Parkinsons Dis. 2019;9(3):603-614. doi:10.3233/JPD-191627

Theme1Dot Baig F, Kelly MJ, Lawton MA, Ruffmann C, Rolinski M, Klein JCBarber TLo CBen-Shlomo Y, Okai D, Hu MT (2019). Impulse control disorders in Parkinson’s and RBD- a longitudinal study of severity. Neurology. 2019;93(7):e675-e687. doi:10.1212/WNL.0000000000007942

 Booth HDE, Wessely F, Connor-Robson N, Rinaldi F, Vowles J, Browne C, Evetts SG, Hu MT, Cowley SA, Webber C, Wade-Martins R. (2019) RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytesNeurobiol Dis. 129:56-66. PMID:31085228

Theme3Dot Condon MD, Platt NJ, Zhang YF, Roberts BM, Clements MA, Vietti-Michelina S, Tseu MY, Brimblecombe KRThrelfell S, Mann EO, Cragg SJ. (2019). Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter. Nature communications, 10(1), pp. 4263. doi: 10.1038/s41467-019-12264-9

Theme3DotTheme1DotTheme2Dot Connor-Robson N, Booth H, Martin JG, Gao B, Li K, Doig N, Vowles J, Browne C, Klinger L, Juhasz P, Klein C, Cowley SA, Bolam P, Hirst W, Wade-Martins R. (2019) An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2Neurobiol Dis. 127:512-526. PMID:30954703


 Theme1Dot Cooray N, Andreotti F, Lo C, Symmonds M, Hu MT, De Vos M. (2019) Detection of REM Sleep Behaviour Disorder by Automated Polysomnography Analysishttps://arxiv.org/abs/1811.04662 PMID:30440668

Theme1Dot Davis S, Scott C, Ansorge O, Fischer R. (2019) Development of a Sensitive, Scalable Method for Spatial, Cell-Type-Resolved Proteomics of the Human BrainJ Proteome Res. 18(4):1787-1795. PMID:30768908

Theme1Dot Guerreiro R, Ross OA, Kun-Rodrigues C, Hernandez DG, Orme T, Eicher JD, Shepherd CE, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Ansorge O, Clarimon J, Lleo A, Morenas-Rodriguez E, Clark L,..., Bras J. (2019) Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. Lancet Neurol. 17(1):64-74. PMID:29263008

Theme1Dot Henderson EJ, Morgan GS, Amin J, Gaunt DM, Ben-Shlomo Y. (2019) The minimum clinically important difference (MCID) for a falls intervention in Parkinson's: A delphi study. Parkinsonism Relat Disord. 61, 106-110. PMID:30455158

Theme1Dot Hu MTM. (2019). From dreams to parkinsonism: tracking the journey. Brain : a journal of neurology, 142(7), pp. 1850-1852. doi: 10.1093/brain/awz155

Theme2DotTheme3Dot Hunn BHM, Vingill S, Threlfell S, Alegre-Abarrategui J, Magdelyns M, Deltheil T, Bengoa-Vergniory N, Oliver PL, Cioroch M, Doig NM, Bannerman DM, Cragg SJ, Wade-Martins R. (2019). Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior. Cell reports, 29(4), pp. 920-931.e7. doi: 10.1016/j.celrep.2019.09.029

 Theme1Dot Jabbari E, Woodside J, Guo T, Magdalinou NK, Chelban V, Athauda D, Lees AJ, Foltynie T, Houlden H, Church A, Hu MT, Rowe JB, Zetterberg H, Morris HR. (2019) Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes. J Neurol Neurosurg Psychiatry. 90(7):768-773. PMID:30867224

Theme1DotTheme2DotTheme3Dot Kelly MJ, Lawton MABaig F, Ruffmann C, Barber TRLo C, Klein JCBen-Shlomo YHu MT. (2019). Predictors of motor complications in early Parkinson's disease: A prospective cohort study. Movement disorders: official journal of the Movement Disorder Society, 34(8), pp. 1174-1183. doi: 10.1002/mds.27783

Theme1Dot Krohn L, Ozturk TN, Vanderperre B, Ruskey JA, Laurent SB, Spiegelman D, Postuma RB, Arnulf I, Hu MTM et al. Genetic, functional, and structural implications of TMEM175 variants in Parkinson disease and REM sleep behavior disorder. Ann Neurol. 2020;87(1):139-153.  doi.org/10.1002/ana.25629

Theme1Dot Lo C, Arora S, Baig F, Lawton MA, El Mouden C, Barber TR, Ruffmann C, Klein JC, Brown P, Ben-Shlomo Y, de Vos M, Hu MT. Predicting motor, cognitive and functional impairment in Parkinson’s. Ann Clin Transl Neurol. 2019;6(8):1498-1509. doi:10.1002/acn3.50853

Theme3DotTheme1DotTheme2Dot Lawton MBaig F, Toulson G, Morovat A, Evetts SGBen-Shlomo YHu MT. (2019). Blood biomarkers with Parkinson's disease clusters and prognosis: the oxford discovery cohort. Movement disorders : official journal of the Movement Disorder Society, doi: 10.1002/mds.27888

Theme2Dot Lang C, Campbell KR, Ryan BJ, Carling P, Attar M, Vowles J, Perestenko OV, Bowden R, Baig F, Kasten M, Hu MT, Cowley SA, Webber C, Wade-Martins R. (2019) Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell PhenotypesCell Stem Cell. 24(1):93-106.e6. PMID:30503143

Theme3Dot Lopes EF, Roberts BM, Siddorn RE, Clements MA, Cragg SJ (2019) Inhibition of nigrostriatal dopamine release by striatal GABAA and GABAB receptorsJ NeurosciPMID:30541909

Theme2Dot  Nizami S, Hall-Roberts H, Warrier S, Cowley SA, Di Daniel E. (2019) Microglial inflammation and phagocytosis in Alzheimer's disease: potential therapeutic targets. Br J Pharmacol. PMID:30740661

Theme1Dot Norwitz NG, Hu MT, Clarke K. (2019) The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of Parkinson's DiseaseFront Nutr. 6:63. eCollection 2019. Review. PMID:31139630

Theme1Dot Postuma RB, Iranzo A, Hu M, Gogl B, Boeve BF et al. Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study. Brain. 2019;142(3):744-759. doi:10.1093/brain/awz03

Theme3Dot Pristerà A, Blomeley C, Lopes E, Threlfell S, Merlini E, Burdakov D, Cragg S, Guillemot F, Ang SL. (2019) Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and explorationProc Natl Acad Sci USA. 116(9):3817-3826. PMID:30808767

Theme3Dot Reis C, Sharott A, Magill PJ, van Wijk BCM, Parr T, Zeidman P, Friston KJ, Cagnan H. (2019) Thalamocortical dynamics underlying spontaneous transitions in beta power in ParkinsonismNeuroimage. 193:103-114. PMID:30862535

Theme1Dot Soundy A, Collett J, Lawrie S, Soe S, Roberts HC, Hu MT et al (2019). A qualitative study on the impact of First Steps- a peer-led, educational intervention for people newly diagnosed with Parkinson’s Disease. Behavioural Sciences Behav. Sci. 2019, 9, 107; doi:10.3390/bs9100107

 Theme1DotTheme2Dot Stefanis L, Emmanouilidou E, Pantazopoulou M, Kirik D, Vekrellis K, Tofaris GK. (2019) How is alpha-synuclein cleared from the cellJ Neurochem. PMID:31069800

Theme1Dot Sundaresan V, Griffanti L, Kindalova P, Alfaro-Almagro F, Zamboni G, Rothwell PM, Nichols TE, Jenkinson M. (2019) Modelling the distribution of white matter hyperintensities due to ageing on MRI images using Bayesian inferenceNeuroimage. 185:434-445. PMID: 30359730

Theme3Dot Szabo A, Tofaris GK. (2019) Monitoring α-Synuclein Proteotoxicity in Drosophila ModelsMethods Mol Biol. 1948:199-208. PMID:30771179

Theme3Dot Wallings R, Connor-Robson NWade-Martins R. (2019). LRRK2 interacts with the vacuolar-type H+-ATPase pump 

Theme2Dot Zambon F, Cherubini M, Fernandes HJR, Lang C, Ryan BJ, Volpato V, Bengoa-Vergniory N, Vingill S, Attar M, Booth HDE, Haenseler W, Vowles J, Bowden R, Webber CCowley SAWade-Martins R. (2019). Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons. Human molecular genetics, 28(12), pp. 2001-2013. doi: 10.1093/hmg/ddz038

Theme3Dot Zhang X-M, Anwar S, Kim Y, Brown J, Comte I, Cai H, Cai N-N, Wade-Martins R, Szele FG (2019) The A30P α-synuclein mutation decreases subventricular zone proliferationHum Mol Genet. 28(14) 2283–2294. 



3 themes




Theme1Dot Ang Y-S, Manoha S, Plant O, Kineast A, Le Heron C, Muhammed K, Hu M, Husain M. Dopamine modulates option generation for behavior. Curr Biol. 2018;28(10):1561-1569.e3.  https://doi.org/10.1016/j.cub.2018.03.069

Theme1Dot Andreotti F, Phan H, Cooray N, Lo C, Hu MTM, De Vos M. (2018) Multichannel Sleep Stage Classification and Transfer Learning using Convolutional Neural Networks. Conf Proc IEEE Eng Med Biol Soc. 171-174. PMID:30440365

Theme1Dot Arora S, Baig F, Lo C, Barber TR, Lawton MA, Zhan A, Rolinski M, Ruffmann C, Klein JC, Rumbold J, Louvel A, Zaiwalla Z, Lennox G, Quinnell T, Dennis G, Wade-Martins R, Ben-Shlomo Y, Little MA, Hu MT. (2018) Smartphone motor testing to distinguish idiopathic REM sleep behavior disorder, controls, and PD. Neurology. 91(16):e1528-e1538. PMID:30232246

 Theme1Dot Barber TR, Griffanti L, Muhammed K, Drew DS, Bradley KM, McGowan DR, Crabbe M, Lo C, Mackay CE, Husain M, Hu MT, Klein JC; Oxford Parkinson's Disease Centre. (2018) Apathy in rapid eye movement sleep behaviour disorder is associated with serotonin depletion in the dorsal raphe nucleusBrain. 141(10):2848-2854. PMID:30212839

Theme1Dot Bencheikh OA, Ruskey B, Arnulf I, Dauvilliers Y, De Cock MC, Gagnon JF, Spiegelman D, Hu MTM et al. LRRK2 protective haplotype and full sequencing study in REM sleep behaviour disorder. Parkinsonism Relat Disord. 2018;52:98-101. doi:10.1016/j.parkreldis.2018.03.019

Theme1Dot Bourgouin PA, Rahayel S, Gaubert M, Arnaldi D, Hu M, Hedbreder A,….Gagnon JF. Neuroimaging of Rapid Eye Movement Sleep Behavior Disorder. Int Rev Neurobiol 2019, 144:185-210. https://doi.org/10.1016/bs.irn.2018.10.006

 Theme1Dot Brainstorm Consortium, …, Sandor C, Webber C, …, Murray R. (2018) Analysis of shared heritability in common disorders of the brainScience. 360(6395). pii: eaap8757. PMID:29930110

 Theme3Dot Brimblecombe KR, Threlfell S, Dautan D, Kosillo P, Mena-Segovia J, Cragg SJ. (2018) Targeted Activation of Cholinergic Interneurons Accounts for the Modulation of Dopamine by Striatal Nicotinic ReceptorseNeuro. 5(5). pii: ENEURO.0397-17.2018. PMID:30406189

Theme1Dot Fiandaca MS, Gross TJ, Johnson TM, Hu MT, Evetts S, Wade-Martins R, Merchant-Borna K, Bazarian J, Cheema AK, Mapstone M, Federoff HJ. (2018) Potential Metabolomic Linkage in Blood between Parkinson's Disease and Traumatic Brain InjuryMetabolites. 8(3). pii:E50. PMID:30205491

Theme2Dot Finelli MJ, Paramo T, Pires E, Ryan BJ, Wade-Martins R, Biggin PC, McCullagh J, Oliver PL. (2018) Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate IsomeraseMol Neurobiol. PMID:29905912

Theme3Dot Garas FN, Kormann E, Shah RS, Vinciati F, Smith Y, Magill PJ, Sharott A. (2018) Structural and molecular heterogeneity of calretinin-expressing interneurons in the rodent and primate striatumJ Comp Neurol. 526(5):877-898 PMID:29218729

 Theme1Dot Griffanti L, Stratmann P, Rolinski M, Filippini N, Zsoldos E, Mahmood A, Zamboni G, Douaud G, Klein JC, Kivimäki M, Singh-Manoux A, Hu MT, Ebmeier KP, Mackay CE. (2018) Exploring variability in basal ganglia connectivity with functional MRI in healthy ageingBrain Imaging and Behavior, 12(6):1822-1827. PMID: 29442271.

Theme1Dot Griffanti L, Jenkinson M, Suri S, Zsoldos E, Mahmood A, Filippini N, Sexton CE, Topiwala A, Allan C, Kivimäki M, Singh-Manoux A, Ebmeier KP, Mackay CE, Zamboni G. (2018) Classification and characterization of periventricular and deep white matter hyperintensities on MRI: A study in older adultsNeuroimage, S1053-8119(17), 30231-8. PMID: 28315460

Theme2Dot Härtlova A, Herbst S, Peltier J, Rodgers A, Bilkei-Gorzo O, Fearns A, Dill BD, Lee H, Flynn R, Cowley SA, Davies P, Lewis PA, Ganley IG, Martinez J, Alessi DR, Reith AD, Trost M, Gutierrez MG. (2018) LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages. EMBO J. 37(12). pii: e98694. PMID:29789389

Theme1Dot Hipp G, Vaillant M, Diederich NJ, Roomp K, Satagopam VP, Banda P, Sandt E, Mommaerts K, Schmitz SK, Longhino L, Schweicher A, Hanff AM, Nicolai B, Kolber P, Reiter D, Pavelka L, Binck S, Pauly C, Geffers L, Betsou F, Gantenbein M, Klucken J, Gasser T, Hu MT, Balling R, Krüger R. (2018) The Luxembourg Parkinson's Study: A Comprehensive Approach for Stratification and Early Diagnosis. (2018) Front Aging Neurosci. 10:326. PMID:30420802

Theme2Dot Jonikas M, Madill M, Mathy A, Zekoll T, Zois CE, Wigfield S, Kurzawa-Akanbi M, Browne C, Sims D, Chinnery PF, Cowley SA, Tofaris GK. (2018) Stem Cell modeling of Mitochondrial Parkinsonism reveals key functions of OPA1. Ann Neurol. PMID:29604226

Theme1Dot Klein JC, Rolinski M, Griffanti L, Szewczyk-Krolikowski K, Baig F, Ruffmann C, Groves AR, Menke RAL, Hu MT, Mackay C. (2018) Cortical structural involvement and cognitive dysfunction in early Parkinson’s diseaseNMR in BiomedicinePMID: 29436039.

 Theme1Dot Lawton M, Ben-Shlomo Y, May MT, Baig F, Barber TR, Klein JC, Swallow DMA, Malek N, Grosset KA, Bajaj N, Barker RA, Williams N, Burn DJ, Foltynie T, Morris HR, Wood NW, Grosset DG, Hu MTM. (2018) Developing and validating Parkinson's disease subtypes and their motor and cognitive progression. J Neurol Neurosurg Psychiatry. 89(12):1279-1287. PMID: 30464029

 Theme1Dot Le Heron C, Plant O, Manohar S, Ang YS, Jackson M, Lennox G, Hu MT, Husain M. (2018) Distinct effects of apathy and dopamine on effort-based decision-making in Parkinson's diseaseBrain. 141(5):1455-1469. PMID:29672668

 Theme1Dot Le Heron C, Manohar S, Plant O, Muhammed K, Griffanti L, Nemeth A, Douaud G, Markus HS, Husain M. (2018) Dysfunctional effort-based decision-making underlies apathy in genetic cerebral small vessel diseaseBrain. 141(11):3193-3210. PMID:30346491

 Theme1Dot Li J, Ruskey JA, Arnulf I, Dauvilliers Y, Hu MTM, Högl B, Leblond CS, Zhou S, Ambalavanan A, Ross JP, Bourassa CV, Spiegelman D, Laurent SB, Stefani A, Charley Monaca C, Cochen De Cock V, Boivin M, Ferini-Strambi L, Plazzi G, Antelmi E, Young P, Heidbreder A, Labbe C, Ferman TJ, Dion PA, Fan D, Desautels A, Gagnon JF, Dupré N, Fon EA, Montplaisir JY, Boeve BF, Postuma RB, Rouleau GA, Ross OA, Gan-Or Z. (2018) Full sequencing and haplotype analysis of MAPT in Parkinson's disease and rapid eye movement sleep behavior disorder. Mov Disord. 33(6):1016-1020. PMID:29756641

 Theme1Dot Ouled Amar Bencheikh B, Ruskey JA, Arnulf I, Dauvilliers Y, Monaca CC, De Cock VC, Gagnon JF, Spiegelman D, Hu MTM, Högl B, Stefani A, Ferini-Strambi L, Plazzi G, Antelmi E, Young P, Heidbreder A, Mollenhauer B, Sixel-Döring F, Trenkwalder C, Oertel W, Montplaisir JY, Postuma RB, Rouleau GA, Gan-Or Z. (2018) LRRK2 protective haplotype and full sequencing study in REM sleep behavior disorder. Parkinsonism Relat Disord. 52:98-101. PMID:29576439

Theme2Dot Rakovic A, Domingo A, Grütz K, Kulikovskaja L, Capetian P, Cowley SA, Lenz I, Brüggemann N, Rosales R, Jamora D, Rolfs A, Seibler P, Westenberger A, König I, Klein C. (2018) Genome editing in induced pluripotent stem cells rescues TAF1 levels in X-linked dystonia-parkinsonism. Mov Disord. 33(7):1108-1118. PMID:30153385

Theme1Dot Ruffmann C, Bengoa-Vergniory N, Poggiolini I, Ritchie D, Hu MT, Alegre-Abarrategui J, Parkkinen L. (2018) Detection of alpha-synuclein conformational variants from gastro-intestinal biopsy tissue as a potential biomarker for Parkinson's disease. Neuropathol Appl Neurobiol. 44(7):722-736. PMID:29676021

Theme1Dot Silverdale MA, Kobylecki C, Kass-Iliyya L, Martinez-Martin P, Lawton M, Cotterill S, Chaudhuri KR, Morris H, Baig F, Williams N, Hubbard L, Hu MT, Grosset DG; UK Parkinson's Pain Study Collaboration. (2018) A detailed clinical study of pain in 1957 participants with early/moderate Parkinson's disease. Parkinsonism Relat Disord. 56:27-32. PMID: 29903584

Theme1Dot Smith AM, Depp C, Ryan BJ, Johnston GI, Alegre-Abarrategui J, Evetts S, Rolinski M, Baig F, Ruffmann C, Simon AK, Hu MTM, Wade-Martins R. (2018) Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells. Mov Disord. 33(10):1580-1590. PMID:30294923

Theme1Dot Thompson AG, Gray E, Thezanas M.L, Charles PD, Evetts S, Hu MT, Talbot K, Fischer R, Kessler BM, Turner MR. Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis. Ann Neurol. 2018;83(2):258-268. doi:10.1002/ana.25143

Theme1Dot Tofaris GK, Buckley NJ. (2018) Convergent molecular defects underpin diverse neurodegenerative diseasesJ Neurol Neurosurg Psychiatry. pii: jnnp-2017-316988. PMID: 29459380

Theme1Dot Valkanova V, Esser P, Demnitz N, Sexton CE, Zsoldos E, Mahmood A, Griffanti L, Kivimäki M, Singh-Manoux A, Dawes H, Ebmeier KP. (2018) Association between gait and cognition in an elderly population based sampleGait Posture. 65:240-245. PMID: 30558938

Theme2Dot Volpato V, Smith J, Sandor C, ..., Webber C, Cader MZ, Lakics V. (2018) Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics StudyStem Cell Reports. 11(4):897-911. PMID:30245212

Theme1Dot Watson LM, Wong MMK, Vowles J, Cowley SA, Becker EBE. (2018) A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells. Cerebellum. 17(4):419-427. PMID:29397531

Theme3Dot West TO, Berthouze L, Halliday DM, Litvak V, Sharott A, Magill PJ, Farmer SF. (2018) Propagation of beta/gamma rhythms in the cortico-basal ganglia circuits of the parkinsonian rat. J Neurophysiol. 119(5):1608-1628. PMID:29357448

 Theme3Dot Zhang YF, Reynolds JNJ, Cragg SJ. (2018) Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with Dopamine Modulation. Neuron. pii: S0896-6273(18)30335-0. PMID:29754751



 Theme1Dot Alexopoulou Z, Lang J, Perrett RM, Elschami M, Hurry ME, Kim HT, Mazaraki D, Szabo A, Kessler BM, Goldberg AL, Ansorge O, Fulga TA, Tofaris GK. (2017) Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease. Proc Natl Acad Sci USA. 113(32):E4688-97. PMID:2744401

 Theme1Dot Baig F, Lawton MA, Rolinski M, Ruffmann C, Klein JC, Nithi K, Okai D, Ben-Shlomo Y, Hu MTM. (2017) Personality and addictive behaviours in early Parkinson’s disease and REM sleep behavior disorder. Park Rel Dis. 37:72-78. PMID:28173973

 Theme2Dot Bailey J, Shaw A, Fischer R, Ryan BJ, Kessler BM, McCullagh J, Wade-Martins R, Channon KM, Crabtree MJ. (2017) A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balanceFree Radic Biol Med. 104:214-225. PMID:28104455

Theme1Dot Barber TR, Muhammed K, Drew D, Lawton M, Crabbe M, Rolinski M, Quinnell T, Zaiwalla Z, Ben-Shlomo Y, Husain M, Hu MT. (2017) Apathy in rapid eye movement sleep behaviour disorder is common and under-recognised. Eur J Neurol. doi: 10.1111/ene.13515. [Epub ahead of print] PMID:29114969

 Theme1Dot Barber TR, Lawton M, Ben-Shlomo Y, Hu MTM. (2017) Considerations in the Use of MDS Research Criteria for Prodromal Parkinson's in Rapid Eye Movement Sleep Behaviour Disorder and Population Cohorts. Sleep. 40(10). PMID:29029243

 Theme1Dot Barber TR, Lawton M, Rolinski M, Evetts S, Baig F, Ruffmann C, Gornall A, Klein JC, Lo C, Dennis G, Bandmann O, Quinnell T, Zaiwalla Z, Ben-Shlomo Y, Hu MT. (2017) Prodromal Parkinsonism and neurodegenerative risk stratification in REM sleep behaviour disorderSleep. PMID:28472425

 Theme1Dot Barber TR, Klein JC, MacKay CE, Hu MT (2017) Neuroimaging in pre-motor Parkinson's diseaseNeuroImage: Clinical 15, 215–227.

Theme2Dot Baud A, Wessely F, Mazzacuva F, McCormick J, Camuzeaux S, Heywood WE, Little D, Vowles J, Tuefferd M, Mosaku O, Lako M, Armstrong L, Webber C, Cader MZ, Peeters P, Gissen P, Cowley SA and Mills K. (2017) A Multiplex High-Throughput Targeted Proteomic Assay To Identify Induced Pluripotent Stem CellsAnalytical Chemistry. 89(4):2440-2448. PMID:28192931

Theme2Dot Beevers JE, Lai MC, Collins E, Booth HDE, Zambon F, Parkkinen L, Vowles J, Cowley SA, Wade-Martins R, Caffrey TM (2017) MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine NeuronsStem Cell Reports. 9(2):587-599. PMID: 28689993

Theme1Dot Bengoa-Vergniory N, Roberts RF, Wade-Martins R, Alegre-Abarrategui J. (2017) Alpha-synuclein oligomers: a new hope. Acta NeuropatholPMID:28803412

Theme2Dot Booth HDE, Hirst WD, Wade-Martins R. (2017) The Role of Astrocyte Dysfunction in Parkinson's Disease Pathogenesis. Trends Neurosci. 40(6):358-370. PMID:28527591

Theme3Dot Brimblecombe KR, Cragg SJ (2017) The striosome and matrix compartments of the striatum: a path through the labyrinth from neurochemistry towards functionACS Chem Neurosci. 8(2):235-242. PMID: 27977131

Theme2Dot Cherubini M, Wade-Martins R. (2017) Convergent pathways in Parkinson's disease. Cell Tissue Res. doi:10.1007/s00441-017-2700-2. PMID:29063175

Theme1Dot  Demnitz N, Zsoldos E, Mahmood A, Mackay CE, Kivimäki M, Singh-Manoux A, Dawes H, Johansen-Berg H, Ebmeier KP, Sexton CE. (2017) Associations between Mobility, Cognition, and Brain Structure in Healthy Older AdultsFront Aging Neurosci. 9:155. PMID: 28588477

Theme3Dot Doucet M, El-Turabi A, Zabel F, Hunn BHM, Bengoa-Vergniory N, Cioroch M, Ramm M, Smith AM, Gomes AC, Cabral de Miranda G, Wade-Martins R, Bachmann MF. (2017) Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles. PLoS One. 12(8):e0181844. PMID:28797124

Theme1Dot Gan-Or Z, Montplaisir JY, Ross JY, Poirier J, Warby SC, Arnulf I, Strong S, Dauvilliers Y, Leblond CS, Hu MTM, Hogl B, Stefani A, Monaca CC, De Cock VC, Boivin M, Ferini-Stambi L, Plazzi G, Antelmi E, Young P, Heidbreber A, Barber TR, Evetts SG, Rolinski M, Dion PA, Desautels A, Gagnon J-F, Dupre N, Postuma RB, Rouleau GA. (2017) The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorderNeurobiology of Aging. 218.e13-218.e15. PMID: 27814994

Theme3Dot González-Cabrera C, Meza R, Ulloa L, Merino-Sepúlveda P, Luco V, Sanhueza A, Oñate-Ponce A, Bolam JP, Henny P. (2017) Characterization of the axon initial segment of mice substantia nigra dopaminergic neuronsJ Comp Neurol. 525(16):3529-3542. PMID:28734032

Theme1Dot Griffanti L, Douaud G, Bijsterbosch J, Evangelisti S, Alfaro-Almagro F, Glasser MF, Duff EP, Fitzgibbon S, Westphal R, Carone D, Beckmann CF, Smith SM. (2017) Hand classification of fMRI ICA noise componentsNeuroimage. 154:188-205. PMID: 27989777

Theme2Dot Haenseler W, Zambon F, Lee H, Vowles J, Rinaldi F, Duggal G, Houlden H, Gwinn K, Wray S, Luk KC, Wade-Martins R, James WS, Cowley SA. (2017) Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages. Sci Rep. 7(1):9003. PMID:28827786

Theme2Dot Haenseler W, Sansom SN, Buchrieser J, Newey SE, Moore CS, Nicholls FJ, Chintawar S, Schnell C, Antel JP, Allen ND, Cader MZ, Wade-Martins R, James WS, Cowley SA. (2017) A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response. Stem Cell Reports. 8(6):1727-1742. PMID:28591653

Theme2Dot Heman-Ackah SM, Manzano R, Hoozemans JJM, Scheper W, Flynn R, Haerty W, Cowley SA, Bassett AR, Wood MJA. (2017) Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neuronsHum Mol Genet. 26(22):4441-4450. PMID:28973645

Theme1Dot Koychev I, Gunn RN, Firouzian A, Lawson J, Zamboni G, Ridha B, Sahakian BJ, Rowe JB, Thomas A, Rochester L, Ffytche D, Howard R, Zetterberg H, MacKay C, Lovestone S; Deep and Frequent Phenotyping study team. (2017) PET Tau and Amyloid-β Burden in Mild Alzheimer's Disease: Divergent Relationship with Age, Cognition, and Cerebrospinal Fluid BiomarkersJ Alzheimers Dis. 60(1):283-293. PMID: 28800330

Theme1Dot Kyle SD, Sexton CE, Feige B, Luik AI, Lane J, Saxena R, Anderson SG, Bechtold DA, Dixon W, Little MA, Ray D, Riemann D, Espie CA, Rutter MK, Spiegelhalder K. (2017) Sleep and cognitive performance: cross-sectional associations in the UK BiobankSleep Med. 38:85-91. PMID: 29031762

Theme2Dot Lai MC, Bechy AL, Denk F, Collins E, Gavriliouk M, Zaugg JB, Ryan BJWade-Martins R, Caffrey TM. (2017) Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders. Mol Neurodegener. 12(1):79. PMID:29084565

Theme1Dot Lane JM, Liang J, Vlasac I, Anderson SG, Bechtold DA, Bowden J, Emsley R, Gill S, Little MA, Luik AI, Loudon A, Scheer FA, Purcell SM, Kyle SD, Lawlor DA, Zhu X, Redline S, Ray DW, Rutter MK, Saxena R. (2017) Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traitsNat Genet. 49(2):274-281. PMID: 27992416

Theme2Dot Lee H, James WS, Cowley SA (2017) LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson’s disease. Biochemical Society Transactions. 45(1):131-139. PMID:28202666

Theme1Dot Li Q, Tofaris GK, Davis JJ. (2017) Concentration-Normalized Electroanalytical Assaying of Exosomal MarkersAnal Chem. 89(5):3184-3190. PMID 28192902

Theme1Dot Lunnon K, Keohane A, Pidsley R, Newhouse S, Riddoch-Contreras J, Thubron EB, Devall M, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Schalkwyk L, Dobson R, Malik AN, Powell J, Lovestone S, Hodges A; (2017) Mitochondrial genes are altered in blood early in Alzheimer's diseaseNeurobiol Aging. 53:36-47. PMID:28208064

Theme1Dot Malek N, Lawton MA, Grosset KA, Bajaj N, Barker RA, Ben-Shlomo Y, Burn DJ, Foltynie T, Hardy J, Morris HR, Williams NM, Wood N, Grosset DG; PRoBaND clinical consortium. (2017) Utility of the new Movement Disorder Society clinical diagnostic criteria for Parkinson's disease applied retrospectively in a large cohort study of recent onset cases. Parkinsonism Relat Disord. S1353-8020(17)30136-0. PMID:28431829

Theme3Dot McMillan KJ, Murray TK, Bengoa-Vergniory N, Cordero-Llana O, Cooper J, Buckley A, Wade-Martins R, Uney JB, O'Neill MJ, Wong LF, Caldwell MA. (2017) Loss of MicroRNA-7 Regulation Leads to α-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo. Mol Ther. 25(10):2404-2414. PMID:28927576

Theme3Dot Mena-Segovia J, Bolam JP (2017) Rethinking the Pedunculopontine Nucleus: From Cellular Organization to FunctionNeuron. 94(1):7-18. PMID: 28384477

Theme1Dot Morgan AR, O'Hagan C, Touchard S, Lovestone S, Morgan BP. (2017) Effects of freezer storage time on levels of complement biomarkersBMC Res Notes. 10(1):559. PMID: 29110694

Theme2Dot Sandor C, Robertson P, Lang C, Heger A, Booth H, Vowles J, Witty L, Bowden R, Hu M, Cowley SA, Wade-Martins R, Webber C. (2017) Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease. Hum Mol Genet. 26(3):552-566. PMID: 28096185

Theme2Dot Sandor C, Honti F, Haerty W, Szewczyk-Krolikowski K, Tomlinson P, Evetts S, Millin S, Keane T, McCarthy S, Durbin R, Talbot K, Hu M, Webber C, Ponting C, Wade-Martins R. (2017) Whole-exome sequencing of 228 patients with sporadic Parkinson’s disease. Scientific Reports. 7:41188. PMID:28117402

Theme1Dot Sexton CE, Zsoldos E, Filippini N, Griffanti L, Winkler A, Mahmood A, Allan CL, Topiwala A, Kyle SD, Spiegelhalder K, Singh-Manoux A, Kivimaki M, Mackay CE, Johansen-Berg H, Ebmeier KP. (2017) Associations between self-reported sleep quality and white matter in community-dwelling older adults: A prospective cohort studyHum Brain Mapp. 38(11):5465-5473. PMID: 28745016

Theme3Dot Sharott A, Vinciati F, Nakamura KC, Magill PJ. (2017) A Population of Indirect Pathway Striatal Projection Neurons Is Selectively Entrained to Parkinsonian Beta OscillationsJ Neurosci. 37(41):9977-9998.

Theme1Dot Silva de Lima AL, Evers LJ, Hahn T, Bataille L, Hamilton JL, Little MA, Okuma Y, Bloem BR, Faber MJ. (2017) Freezing of gait and fall detection in Parkinson's disease using wearable sensors: a systematic review. J Neurol. PMID:28251357

Theme1Dot Silva de Lima AL, Hahn T, Evers LJW, de Vries NM, Cohen E, Afek M, Bataille L, Daeschler M, Claes K, Boroojerdi B, Terricabras D, Little MA, Baldus H, Bloem BR, Faber MJ. (2017) Feasibility of large-scale deployment of multiple wearable sensors in Parkinson's diseasePLoS One. 12(12):e0189161. PMID: 28847810

Theme1Dot Straniero L, Guella I, Cilia R, Parkkinen L, Rimoldi V, Young A, Asselta R, Soldà G, Sossi V, Stoessl AJ, Priori A, Nishioka K, Hattori N, Follett J, Rajput A, Blau N, Pezzoli G, Farrer MJ, Goldwurm S, Rajput AH, Duga S. (2017) DNAJC12 and dopa-responsive nonprogressive parkinsonismAnn Neurol. 82(4):640-646. PMID: 28892570

Theme1Dot Suri S, Topiwala A, Filippini N, Zsoldos E, Mahmood A, Sexton CE, Singh-Manoux A, Kivimäki M, Mackay CE, Smith S, Ebmeier KP. (2017) Distinct resting-state functional connections associated with episodic and visuospatial memory in older adultsNeuroimage.159:122-130. PMID: 28756237

Theme1Dot Suri S, Emir U, Stagg CJ, Near J, Mekle R, Schubert F, Zsoldos E, Mahmood A, Singh-Manoux A, Kivimäki M, Ebmeier KP, Mackay CE, Filippini N. (2017) Effect of age and the APOE gene on metabolite concentrations in the posterior cingulate cortexNeuroimage. 152:509-516. PMID: 28323160

Theme1Dot Tofaris GK. (2017) A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson's DiseaseJ Parkinsons Dis. 7(4):569-576. PMID: 28922170

Theme1Dot Tofaris GK, Goedert M, Spillantini MG. (2017) The Transcellular Propagation and Intracellular Trafficking of α-Synuclein. Cold Spring Harb Perspect Med. 7(9). pii: a024380. PMID: 27920026

Theme1Dot Topiwala A, Allan CL, Valkanova V, Zsoldos E, Filippini N, Sexton C, Mahmood A, Fooks P, Singh-Manoux A, Mackay CE, Kivimäki M, Ebmeier KP. (2017) Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study. BMJ. 357:j2353. PMID: 28588063

Theme3Dot  Vargas-Caballero M, Denk F, Wobst HJ, Arch E, Pegasiou CM, Oliver PL, Shipton OA, Paulsen O, Wade-Martins R. (2017) Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau-/- miceFront Neurosci. 11:201. PMID:28484365

Theme3Dot Vingill S, Connor-Robson N, Wade-Martins R. (2017) Are rodent models of Parkinson's disease behaving as they should? Behav Brain Res. pii: S0166-4328(17)30592-2. PMID:29074404

Theme1Dot Wei W, Keogh MJ, Wilson I, Coxhead J, Ryan S, Rollinson S, Griffin H, Kurzawa-Akanbi M, Santibanez-Koref M, Talbot K, Turner MR, McKenzie CA, Troakes C, Attems J, Smith C, Al Sarraj S, Morris CM, Ansorge O, Pickering-Brown S, Ironside JW, Chinnery PF. (2017) Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains. Acta Neuropathol Commun. 5(1):13. Erratum in: Acta Neuropathol Commun. 2017 Feb 22;5(1):17. PMID:28153046

Theme1Dot Westwood S, Liu B, Baird AL, Anand S, Nevado-Holgado AJ, Newby D, Pikkarainen M, Hallikainen M, Kuusisto J, Streffer JR, Novak G, Blennow K, Andreasson U, Zetterberg H, Smith U, Laakso M, Soininen H, Lovestone S. (2017) The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathologyAlzheimers Res Ther. 9(1):31. PMID:28441961

Theme3Dot Wobst HJ, Denk F, Oliver PL, Livieratos A, Taylor TN, Knudsen MH, Bengoa-Vergniory N, Bannerman D and Wade-Martins R (2017) Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathyScientific Reports. 7:43198. PMID:28233851

Theme3Dot Zhang YF, Cragg SJ. (2017) Pauses in Striatal Cholinergic Interneurons: What is Revealed by Their Common Themes and VariationsFront Syst Neurosci. 11:80. PMID: 29163075



Theme1DotTheme3Dot Dodson PD, Dreyer JK, Jennings KA, Syed EC, Wade-Martins R, Cragg SJ, Bolam JP, Magill PJ (2016) Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonismPNAS, 113(15):E2180-8. PMID: 27001837.

Theme1Dot Espay AJ, Bonato P, Nahab FB, Maetzler W, Dean JM, Klucken J, Eskofier BM, Merola A, Horak F, Lang AE, Reilmann R, Giuffrida J, Nieuwboer A, Horne M, Little MA, Litvan I, Simuni T, Dorsey ER, Burack MA, Kubota K, Kamondi A, Godinho C, Daneault JF, Mitsi G, Krinke L, Hausdorff JM, Bloem BR, Papapetropoulos S. (2016) Technology in Parkinson's disease: Challenges and opportunities. Movement DisordersPMID:27125836

Theme1Dot Fairfoul G, McGuire LI, Pal S, Ironside JW, Neumann J, Christie S, Joachim C, Esiri M, Evetts SG, Rolinski M, Baig F, Ruffmann C, Wade-Martins R, Hu MTM, Parkkinen L and Green AJE (2016) Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathiesAnnals of Clinical and Translational Neurology. doi: 10.1002/acn3.338

Theme2Dot Fernandes HJRHartfield EM, Christian HC, Emmanoulidou E, Zheng Y, Booth H, Bogetofte H, Lang C, Ryan BJ, Sardi SP, Badger J, Vowles J, Evetts S, Tofaris GK, Vekrellis K, Talbot K, Hu MT, James W, Cowley SA, Wade-Martins R (2016) ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine NeuronsStem Cell Reports. 6(3):342-56.  PMID:26905200

 Theme3Dot Garas FN, Shah RS, Kormann E, Doig NM, Vinciati F, Nakamura KC, Dorst MC, Smith Y, Magill PJ, Sharott A. (2016)  Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons. Elife. 5. pii: e16088. PMID:27669410

Theme1Dot Griffanti L, Rolinski M, Szewczyk-Krolikowski K, Menke RA, Filippini N, Zamboni G, Jenkinson M, Hu MT, Mackay CE. (2016) Challenges in the reproducibility of clinical studies with resting state fMRI: An example in early Parkinson's diseaseNeuroimage. 2016 Jan 1; 124(Pt A): 704–713. PMID:26386348

Theme2Dot Handel AE, Chintawar S, Lalic T, Whiteley E, Vowles J, Giustacchini A, Argoud K, Sopp P, Nakanishi M, Bowden R, Cowley S, Newey S, Akerman C, Ponting CP, Cader MZ. (2016) Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single cell transcriptomics. Human Molecular Genetics. 25(5):989-1000. PMID: 26740550.

Theme2Dot Keane H, Ryan BJ, Jackson B, Whitmore A, Wade-Martins R. (2016) Protein-protein interaction networks identify targets which rescue the MPP+ cellular model of Parkinson's diseaseSci Rep. 5:17004. PMID:26608097

Theme3Dot Kosillo P, Zhang YF, Threlfell S, Cragg SJ. (2016) Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons. Cereb Cortex. PMID:27566978

Theme1Dot Kubota K, Chen J, Little MA (2016) Machine learning for large-scale wearable sensor data in Parkinson. disease: concepts, promises, pitfalls and futures. Movement Disorders Movement DisordersPMID:27501026

Theme1Dot Lane JM, Vlasac I, Anderson SG, Kyle SD, Dixon WG, Bechtold DA, Gill S, Little MA, Luik A, Loudon A, Emsley R, Scheer FA, Lawlor DA, Redline S, Ray DW, Rutter MK, Saxena R. (2016) Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UKBiobankNature Communications7:10889. PMID:26955885

Theme1Dot Lawton M, Hu MT, Baig F, Ruffmann C, Barron E, Swallow DM, Malek N, Grosset KA, Bajaj N, Barker RA, Williams N, Burn DJ, Foltynie T, Morris HR, Wood NW, May MT, Grosset DG, Ben-Shlomo Y. (2016) Equating scores of the University of Pennsylvania Smell Identification Test and Sniffin' Sticks test in patients with Parkinson's disease. Parkinsonism Relat Disord. S1353-8020(16)30381-9. PMID:27729202

Theme1Dot Malek N, Lawton MA, Swallow DM, Grosset KA, Marrinan SL, Bajaj N, Barker RA, Burn DJ, Hardy J, Morris HR, Williams NM, Wood N, Ben-Shlomo Y, Grosset DG; PRoBaND Clinical Consortium. (2016) Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson's disease. Mov Disord. PMID:27324570

Theme1Dot Miller KL, Alfaro-Almagro F, Bangerter NK, Thomas DL, Yacoub E, Xu J, Bartsch AJ, Jbabdi S, Sotiropoulos SN, Andersson JLR, Griffanti L, Douaud G, Okell TW, Weale P, Dragonu I, Garratt S, Hudson S, Collins R, Jenkinson M, Matthews PM & Smith SM (2016) Multimodal population brain imaging in the UK Biobank prospective epidemiological studyNature Neuroscience. doi.10.1038/nn.4393

Theme1Dot Muhammed K, Manohar S, Ben Yehuda M, Chong TT, Tofaris G, Lennox G, Bogdanovic M, Hu M, Husain M. (2016) Reward sensitivity deficits modulated by dopamine are associated with apathy in Parkinson's disease. Brain. PMID:27452600

Theme1Dot Panouillères MT, Tofaris GK, Brown P, Jenkinson N. (2016) Intact Acquisition and Short-Term Retention of Non-Motor Procedural Learning in Parkinson's DiseasePLOS ONE. 11(2):e0149224. PMID: 26906905

Theme1Dot Y.P. Raykov, A. Boukouvalas, F. BaigM.A. Little. (2016) What to do when K-means clustering fails: a simple yet principled alternative algorithm
PLoS Onedoi.org/10.1371/journal.pone.0162259

Theme1Dot Rolinski MGriffanti L, Piccini P, Roussakis AA, Szewczyk-Krolikowski K, Menke RA, Quinnell T, Zaiwalla Z, Klein JC, Mackay CE, Hu MT. (2016) Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson's disease. BrainPMID: 27297241

Theme1Dot Ruffmann C, Parkkinen L. (2016) Gut Feelings About α-Synuclein in Gastrointestinal Biopsies: Biomarker in the Making? Movement Disorders. 31(2):193-202. PMID: 26799450.

Theme1Dot Silva de Lima AL, Hahn T, de Vries NM, Cohen E, Bataille L, Little MA, Baldus H, Bloem BR, Faber MJ. (2016) Large-Scale Wearable Sensor Deployment in Parkinson's Patients: The Parkinson@Home Study Protocol. JMIR Res Protoc. 5(3):e172. PMID:27565186

Theme3Dot Sloan M, Alegre-Abarrategui J, Potgieter D, Kaufmann AK, Exley R, Deltheil T, Threlfell SConnor-Robson N, Brimblecombe K, Wallings R, Cioroch M, Bannerman DM, Bolam JP, Magill PJ, Cragg SJ, Dodson PD, Wade-Martins R (2016)LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit functionHuman Molecular Genetics. 25(5):951-63. PMID: 26744332

Theme1Dot Silva de Lima AL, Hahn T, de Vries NM, Cohen E, Bataille L, Little MA, Baldus H, Bloem BR, Faber MJ. (2016) Swallow DM, Lawton MA, Grosset KA, Malek N, Klein J, Baig F, Ruffmann C, Bajaj NP, Barker RA, Ben-Shlomo Y, Burn DJ, Foltynie T, Morris HR, Williams N, Wood NW, Hu MT, Grosset DG. (2016) Statins are underused in recent-onset Parkinson's disease with increased vascular risk: findings from the UK Tracking Parkinson's and Oxford Parkinson's Disease Centre (OPDC) discovery cohorts. J Neurol Neurosurg Psychiatry. 87(11):1183-1190. PMID:27671901

 Theme1Dot  Swallow DM, Lawton MA, Grosset KA, Malek N, Klein J, Baig F, Ruffmann C, Bajaj N, Barker RA, Ben-Shlomo Y, Burn DJ, Foltynie T, Morris HR, Williams N, Wood NW, Hu MTM, Grosset DG. Statins are underused in recent-onset Parkinson’s disease with increased vascular risk: findings from the UK Tracking Parkinson’s and Oxford Parkinson’s Disease Centre (OPDC) discovery cohorts. J Neurol Neurosurg Psychiatry. 2016;87(11):1183-1190. doi:10.1136/jnnp-2016-313642

Theme1Dot Tofaris GK, Goedert M, Spillantini MG. (2016) The Transcellular Propagation and Intracellular Trafficking of α-Synuclein. Cold Spring Harb Perspect Med. pii: a024380. PMID:27920026

Theme2Dot Vazquez-Arango P, Vowles J, Browne C, Hartfield E, Fernandes HJ, Mandefro B, Sareen D, James W, Wade-Martins RCowley SA, Murphy S, O'Reilly D. (2016) Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular diseaseNucleic Acids Res.  pii: gkw711. PMID:27536002



Theme3Dot Abdi A, Mallet N, Mohamed FY, Sharott A, Dodson PD, Nakamura KC, Suri S, Avery S V., Larvin JT, Garas FN, Garas SN, Vinciati F, Morin S, Bezard E, Baufreton J, Magill PJ. (2015) Prototypic and Arkypallidal Neurons in the Dopamine-Intact External Globus Pallidus.  J Neurosci 35:6667–6688. PMID: 25926446

Theme1Dot Antoniades CA, Demeyere N, Kennard C, Humphreys GW, Hu MT. (2015) Antisaccades and executive dysfunction in early drug-naive Parkinson's disease: The discovery study. Mov Disord. 30(6):843-7. PMID: 25600361

Theme1Dot Baig F, Lawton M, Rolinski M, Ruffmann C, Nithi K, Evetts SG, Fernandes HR, Ben-Shlomo Y, Hu MT. (2015) Delineating Non-Motor Symptoms in Early Parkinson’s Disease and First Degree RelativesMov Disord. 30(13):1759-66. PMID:26179331

Theme3Dot Brimblecombe KR, Gracie CJ, Platt NJ, Cragg SJ (2015) Gating of dopamine transmission by calcium and axonal N, Q, T and L-type voltage-gated calcium channels differs between striatal domains. J Physiol. 593: 929-946. PMID: 25533038

Theme1Dot Chong T.T, Bonnelle V, Manohar S, Veromann K.R, Muhammed K, Tofaris G.K, Hu MT, Husain M. (2015) Dopamine enhances willingness to exert effort for reward in Parkinson’s disease. Cortex, 69:40-46. PMID: 25967086

Theme3Dot Dodson PD, Larvin JT, Duffell JM, Garas FN, Doig NM, Kessaris N, Duguid IC, Bogacz R, Butt SJ, Magill PJ. (2015) Distinct developmental origins manifest in the specialized encoding of movement by adult neurons of the external globus pallidus. Neuron. 86(2):501-13. PMID: 25843402 

Theme1Dot Griffanti LRolinski MSzewczyk-Krolikowski K, Menke RA, Filippini N, Zamboni G, Jenkinson M, Hu MTMackay CE. (2015) Challenges in the reproducibility of clinical studies with resting state fMRI: An example in early Parkinson's diseaseNeuroimage. 124(Pt A):704-13. PMID:26386348

Theme1Dot Guerreiro R, Escott-Price V, Darwent L, Parkkinen L, Ansorge O, Hernandez DG, Nalls MA, Clark L, Honig L, Marder K, van der Flier W, Holstege H, Louwersheimer E, Lemstra A, Scheltens P, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Ortega-Cubero S, Pastor P, Ferman TJ, Graff-Radford NR, Ross OA, Barber I, Braae A, Brown K, Morgan K, Maetzler W, Berg D, Troakes C, Al-Sarraj S, Lashley T,Compta Y, Revesz T, Lees A, Cairns NJ, Halliday GM, Mann D, Pickering-Brown S, Powell J, Lunnon K, Lupton MK; International Parkinson's Disease Genomics Consortium (IPDGC), Dickson D, Hardy J, Singleton A, Bras J. (2015) Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases. Neurobiology of Aging. 38:214.e7-10. PMID:26643944

Theme3Dot Hunn BHM, Cragg SJ, Bolam JP, Spillantini MG, Wade-Martins R (2015). Impaired intracellular trafficking defines early Parkinson’s diseaseTrends Neurosci. 38:178-188. PMID: 2563977

Theme2Dot Keane HRyan BJ, Jackson B, Whitmore A, Wade-Martins R (2015). Protein-protein interaction networks identify targets which rescue the MPP(+) cellular model of Parkinson's disease. Scientific Reports. 5:17004. PMID:26608097

Theme3Dot Kosillo P, Brimblecombe K, Threlfell S, Cragg SJ (2015). Coupling optogenetics with voltammetry. In: Compendium of In Vivo Monitoring in Real-Time Molecular Neuroscience: Volume 1 - Fundamentals and Applications (Eds GS Wilson, AC Michael), World Scientific Publishing Co., Singapore, 2014, Ch 9, pp 201-223,

Theme1Dot Lawton MBaig FRolinski MRuffman C, Nithi K, May MT, Ben-Shlomo YHu MT (2015) Parkinson's Disease Subtypes in the Oxford Parkinson Disease Centre (OPDC) Discovery CohortJournal of Parkinson's Disease 5, p269-279. PMID:26405788

 Theme1Dot Lawton M, Kasten M, May MT, Mollenhauer B, Schaumburg M, Liepelt-Scarfone I, Maetzler W, Vollstedt E-J, Hu MTM, Berg D, Ben-Shlomo Y. Validation of conversion between Mini-Mental State Examination and Montreal Cognitive Assessment. Mov Disord. 2016;31(4):593-596. doi:10.1002/mds.26498

 Theme3Dot Pristerà A, Lin W, Kaufmann A-K, Brimblecombe KR, Threlfell S, Dodson PD, Magill PJ, Fernandes C, Cragg SJ, and Ang S-L (2015) Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice. PNAS, 112(35):E4929-38. PMID 26283356

Theme1DotTheme2Dot  Roberts RF, Wade-Martins R, Alegre-Abarrategui J (2015) Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain. Brain, 138(Pt 6):1642-57. PMID:25732184

Theme1Dot Rolinski M, Griffanti L, Szewczyk-Krolikowski K, Menke R, Wilcock G, Filippini N, Zamboni G, Hu MT, Mackay CE (2015) Aberrant functional connectivity within the basal ganglia of patients with Parkinson's disease. NeuroImage: Clinical, 8: 126-132. PMID:26106536

Theme1Dot Rolinski M, Zokaei N, Baig F, Giehl K, Quinnell T, Zaiwalla Z, Mackay CE, Husain M, Hu MT (2015) Visual short-term memory deficits in REM sleep behaviour disorder mirror those in Parkinson’s diseaseBrain. 139(Pt 1):47-53. PMID:26582557

Theme2Dot Ryan BJ, Crabtree MJ, Channon KM and Wade-Martins R (2015) Letter to editor: Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers. Brain. 138(Pt 5):e348. PMID: 25398233

Theme2Dot Ryan BJ, Hoek S, Fon EA, Wade-Martins R. (2015) Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease. Trends Biochem Sci. 40(4): 200–210. PMID:25757399

Theme2Dot Silva AM, Brown JM, Buckle VJ, Wade-Martins R and Lufino MMP (2015) Expanded GAA repeats impair FXN gene expression and reposition the FXN locus to the nuclear lamina in single cells. Human Molecular Genetics; 24(12):3457-71. PMID: 25814655

Theme1Dot Stephenson D, Hu MT, Romero K, Breen K, Burn D, Ben-Shlomo Y, Bhattaram A, Isaac M, Venuto C, Kubota K, Little MA, Friend S, Lovestone S, Morris HR, Grosset D, Sutherland M, Gallacher J, Williams-Gray C, Bain LJ, Avilés E, Marek K, Toga AW, Stark Y, Forrest Gordon M, Ford S. (2015) Precompetitive Data Sharing as a Catalyst to Address Unmet Needs in Parkinson's Disease. Journal of Parkinson's Disease 5(3):581-94 PMID:26406139

Theme1Dot Tomlinson PR, Zheng Y, Fischer R, Heidasch R, Gardiner C, Evetts S, Hu M, Wade-Martins R, Turner M.R., Morris J, Talbot K, Kessler KM and Tofaris GK (2015) Identification of distinct circulating exosomes in Parkinson's disease. Annals of Clinical and Translational Neurology
2(4):353-61. PMID:25909081

Theme1Dot Vaikath NN, Majbour NK, Paleologou KE, Ardah MT, van  Dam E, van  de  Berg WDJ, Forrest SL, Parkkinen L, Gai W-P, Hattori N, Takanashi,  Lee S-J, Mann DMA, Imai Y, Halliday GM, Li J-Y, El-Agnaf OMA (2015) Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology. Neurobiology of Diseases. 79:81-99. PMID:25937088



Theme1Dot Alafuzoff I, Parkkinen L. (2014) Staged pathology in Parkinson's Disease. Parkinsonism & Related Disorders. 20(S1): S57-61. PMID:24262190

Theme2Dot Badger JL, Cordero-Llana O, Hartfield EM, Wade-Martins R. (2014) Parkinson's Disease in a dish - using stem cells as a molecular tool. Neuropharmacology. 76(A) 88-96. PMID:24035919

Theme1Dot Bras J, Guerreiro R, Darwent L, Parkkinen L, Ansorge O, Escott-Price V, Hernandez  DG, Nalls M, Clark L, Honig L, Marder K, van der Flier W, Lemstra E, Scheltens P, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Ortega-Cubero S, Pastor P, Ferman TJ, Graff-Radford NR, Ross OA, Barber I, Braae A, Brown K, Morgan K, Maetzler W, Berg D, Troakes C, Al-Sarraj S, Lashley T, ComptaY, Revesz T, Lees A, Cairns N, Halliday GM, Mann D, Pickering-Brown S, Dickson D, Singleton S, Hardy J (2014) Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of Dementia with Lewy Bodies. Hum Mol Genet. 23(23):6139-46. PMID:24973356

Theme1Dot Compta Y, Parkkinen L, Kempster P, Selikhova M, Lashley T, Holton JL, Lees AJ, Revesz T. (2014) The Significance of α-Synuclein, Amyloid-β and Tau Pathologies in Parkinson's Disease Progression and Related Dementia. Neurodegener Dis. 13(2-3) 154-6. PMID:24028925

Theme1Dot Davies SE, Hallett PJ, Moens T, Smith G, Mangano E, Kim HT, Goldberg AL, Liu JL, Isacson O, Tofaris GK. (2014) Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease. Neurobiol Dis. 64:79-87. PMID:24388974

Theme2Dot Hartfield, E.M., Yamasaki-Mann, M., Ribeiro Fernandes, H.J., Vowles, J., James, W.S., Cowley, S.A. and Wade-Martins, R. (2014) Physiological characterisation of human iPS-derived dopaminergic neurons. PLoS ONE 9(2): e87388 PMID:24586273

Theme3Dot Henny P, Brown MT, Micklem BR, Magill PJBolam JP. (2014) Stereological and ultrastructural quantification of the afferent connectome of individual neurons. Brain Struct Funct. 219(2):631-40 PMID: 23479177

Theme1Dot Hu M, Szewczyk-Krolikowski K, Tomlinson P, Nithi K, Rolinski M, Murray C, Talbot K, Ebmeier K, Ben-Shlomo Y. (2014) Predictors of cognitive impairment in an early stage Parkinson’s disease cohort.  Movement Disorders. 29(3):351-9 PMID:24395708

Theme3Dot Martinez-Gonzalez C, van Andel J, Bolam JP, Mena-Segovia J. (2014) Divergent motor projections from the pedunculopontine nucleus are differentially regulated in Parkinsonism. Brain Struct Funct. 219(4):1451-62. PMID:23708060

Theme1Dot Menke RASzewczyk-Krolikowski K, Jbabdi S, Jenkinson M, Talbot K, Mackay CE, Hu M. (2014) Comprehensive morphometry of subcortical grey matter structures in early-stage Parkinson's disease. Hum Brain Mapp. 35(4): 1681-90. PMID:23861334

Theme3Dot Nevado-Holgado, A.J., Mallet, N., Magill, P.J., Bogacz, R. (2014) Effective connectivity of the subthalamic nucleus-globus pallidus network during Parkinsonian oscillations. Journal of Physiology. 592(Pt 7):1429-55. PMID:  24344162 See comment (Slaves to the rhythm: coupling of the subthalamic nucleus–globus pallidus network in Parkinsonian oscillations)

Theme1Dot Parkkinen L, Lees AJ. (2014) Is levodopa toxic? Insights from pathological studies. Focus on Parkinson’s Disease. 24(1): 16 – 20.

Theme2Dot Roberts TC, Morris KV, Wood MJ. (2014) The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease.
Philos Trans R Soc Lond B Biol Sci. 369(1652). pii: 20130507. PMID: 25135968

Theme1Dot Rolinski M, Szewczyk-Krolikowski K, Tomlinson PR, Nithi K, Talbot K, Ben-Shlomo Y, Hu MT. (2014) REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease. J Neurol Neurosurg Psychiatry. 85(5):560-6. PMID:24187013

Theme2Dot Ryan BJ, Lourenço-Venda L, Crabtree MJ, Hale AB, Channon KM and Wade-Martins R. (2014) α-synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of PD. Free Radical Biology and Medicine 67:58-68. PMID:24148766

Theme1Dot Szewczyk-Krolikowski K, Menke RAL, Rolinski M, Duff E, Salimi-Khorshidi G, Filippini N, Zamboni G, Hu MTM and Mackay CE (2014) Functional connectivity in the basal ganglia network differentiates PD patients from controls. Neurology, 83(3): 208–214. PMID:24920856

Theme1Dot Szewczyk-Krolikowski K, Tomlinson P, Nithi K, Wade-Martins, R., Talbot K, Ben-Shlomo Y and Hu M (2014) The influence of age and gender on motor and non-motor features of early Parkinson's disease: Initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort.  Parkinsonism & Related Disorders 20(1):99-105. PMID:24183678

Theme3Dot Taylor TN, Potgieter D, Anwar S, Senior SL, Janezic S, Threlfell S, Parkkinen L, Livieratos A, Oliver PL, Jennings KA, Davies KE, Ansorge O, Bannerman DM, Cragg SJ, Wade-Martins R. (2014) Region-specific deficits in dopaminergic, but not norepinephrinergic, signaling in a novel A30P-synuclein BAC transgenic mouse. Neurobiol Dis. 62(100): 193–207. PMID:24121116

Theme1Dot  Xu Q, Evetts S, Hu M, Talbot KWade-Martins R, Davis JJ (2014). An impedimetric assay of α-synuclein autoantibodies in early stage Parkinson's disease. RSC Advances 4(102): 58773-58777. DOI: 10.1039/C4RA10100F

Theme1Dot Zokaei N, McNeill A, Proukakis C, Beavan M, Jarman P, Korlipara P, Hughes D, Mehta A, Hu MT, Schapira AH, Husain M. (2014) Visual short-term memory deficits associated with GBA mutation and Parkinson's disease. Brain, 137(8): 2303-11. PMID:24919969




Theme2Dot Beevers, J.E., Caffrey, T.M., Wade-Martins, R. (2013) Induced pluripotent stem-cell (iPSC)-derived dopaminergic models of Parkinson's disease. Biochem. Soc. Trans. 41(6). PMID:24256244

Theme1Dot Douaud G, Menke RA, Gass A, Monsch AU, Rao A, Whitcher B, Zamboni G, Matthews PM, Sollberger M, Smith S. (2013) Brain microstructure reveals early abnormalities more than two years prior to clinical progression from mild cognitive impairment to Alzheimer's disease. J Neurosci. 30;33(5):2147-55. PMID: 23365250

Theme2Dot Heman-Ackah SM, Hallegger M, Rao MS, Wood MJ. (2013) RISC in PD: the impact of microRNAs in Parkinson's disease cellular and molecular pathogenesis. Front Mol Neurosci. 20;6:40. PMID:24312000

Theme3Dot Janezic S, Threlfell S, Dodson PD, Dowie MJ, Taylor TN, Potgieter D, Parkkinen L, Senior SL, Anwar S, Ryan B, Deltheil T, Kosillo P, Cioroch M, Wagner K, Ansorge O, Bannerman DM, Bolam JP, Magill PJ, Cragg SJ, Wade-Martins R. (2013) Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson’s model. Proc Natl Acad Sci USA. 110(24) PMID:24082145

Theme2Dot Lufino MM, Silva AM, Németh AH, Alegre-Abarrategui J, Russell AJ, Wade-Martins R. (2013) A GAA repeat expansion reporter model of Friedreich's ataxia recapitulates the genomic context and allows rapid screening of therapeutic compounds. Hum Mol Genet. 22(25):5173-87. PMID: 23943791



 Theme2Dot Ryan BJ, Lourenço-Venda L, Crabtree MJ, Hale AB, Channon KM and Wade-Martins R (2013) α-synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of PD. Free Radic Biol Med. 67C:58-68. PMID: 24148766

Theme2Dot Thomas M, Alegre-Abarrategui J, Wade-Martins R. (2013) RNA dysfunction and aggrephagy at the centre of an amyotrophic lateral sclerosis/frontotemporal dementia disease continuum. Brain. 136(Pt 5): 1345-60. PMID:23474849

Theme3Dot Threlfell S, West AR. (2013) Review: Modulation of striatal neuron activity by cyclic nucleotide signaling and phosphodiesterase inhibition. Basal Ganglia. 3(3):137-146. PMID: 24490129

Theme2Dot van Wilgenburg B, Browne C, Vowles JCowley SA. (2013) Efficient, Long Term Production of Monocyte-Derived Macrophages from Human Pluripotent Stem Cells under Partly-Defined and Fully-Defined Conditions. PLoS One. 8(8):e71098. PMID:23951090




 Theme3Dot Bolam, J.P. and Pissadaki, E. (2012) Living on the edge with too many mouths to feed: why dopamine neurons die. Movement Disorders. 27(12):1478-83. PMID:23008164

Theme2Dot Hartfield, E. M., Fernandes, H. J., Vowles, J., Cowley, S. A., and Wade-Martins, R. (2012). Cellular reprogramming: a new approach to modelling parkinson's disease. Biochemical Society Transactions, 40(5):1152-1157. PMID:2298888

Theme1Dot Menke RA, Abraham I, Thiel CS, Filippini N, Knight S, Talbot K, Turner MR. (2012) Fractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis. Arch Neurol. 69(11):1493-9. PMID: 22910997

Theme2Dot Sibley CR, Seow Y, Curtis H, Weinberg MS and Wood MJA. (2012) Silencing of Parkinson's disease associated genes with artificial mirtron mimics of miR-1224. Nucleic Acids Res. 40(19):9863-75. PMID: 22848108

Theme3Dot Sloan M, Alegre-Abarrategui J, Wade-Martins R. (2012) Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models. Biochem Soc Trans. 2012 40:1080-5. PMID: 22988869

Theme3Dot Threlfell S, Lalic T, Platt NJ, Jennings KA, Deisseroth K, Cragg SJ. (2012) Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons. Neuron 75:58-64. PMID:22794260 (See Preview by Surmeier and Graybiel (2012) Neuron 75:1-3)

 Theme1Dot  Tofaris GK. (2012) Lysosome-dependent pathways as a unifying theme in Parkinson’s disease. Mov. Disorders Sep 15;27(11):1364-9. PMID:22927213



Theme3Dot Anwar S, Peters O, Millership S, Ninkina N, Doig N, Connor-Robson N, Threlfell S, Kooner G, Deacon RM, Bannerman DM, Bolam JP, Chandra SS, Cragg SJ, Wade-Martins R, Buchman VL. (2011) Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family. J Neurosci. 31(20):7264-74. PMID:21593311

Theme1Dot Compta Y*, Parkkinen L*, O'Sullivan SS, Vandrovcova J, Holton JL, Collins C, Lashley T, Kallis C, Williams DR, de Silva R, Lees AJ, Revesz T (*authors contributed equally) (2011)  Lewy- and Alzheimer type pathologies in Parkinson's disease dementia: which is more important? Brain. 134:1493-505. PMID: 21596773

Theme1Dot Gallagher DA, Parkkinen L, O'Sullivan SS, Spratt A, Shah A, Davey CC, Bremner FD, Revesz T, Williams DR, Lees AJ, Schrag A. (2011) Testing an aetiological model of visual hallucinations in Parkinson's disease. Brain. 134(Pt 11):3299-309. PMID: 21921019

Theme1Dot Hu MT, Butterworth R, Kumar V, Cooper J, Jones E, Catterall L, Ben-Shlomo Y (2011) How common and what are the determinants of sub-optimal care for Parkinson's disease patients: the Milton Keynes community study. Parkinsonism Relat Disord. 17(3):177-81. PMID:21239210

Theme1Dot Hu M, Cooper J, Beamish R, Jones E, Butterworth R, Catterall L, Ben-Shlomo Y. (2011) How well do we recognise non-motor symptoms in a British Parkinson's disease population? J Neurol. 258(8):1513-7. PMID: 21394490

Theme1Dot Parkkinen L, O'Sullivan S, Kuoppamaki M, Holton JL, Revesz T, Lees AJ. (2011) Does levodopa accelerate the pathologic process in Parkinson disease brain? Neurology. 77(15):1420-6. PMID:21917769

Theme1Dot Parkkinen L, O’Sullivan S, Collins C, Petrie A, Holton JL, Revesz T, Lees AJ. (2011) Disentangling the relationship between Lewy bodies and nigral neuronal loss in Parkinson’s disease. Journal of Parkinson’s Disease (3):277-86. PMID:23939308

Theme3Dot Rice ME, Patel JC, Cragg SJ (2011). Dopamine release in the basal ganglia. Neuroscience, 198:112-37. PMID:21939738

Theme2Dot Sibley CR, Wood MJA. (2011) Identification of allele-specific RNAi effectors targeting genetic forms of Parkinson’s disease. PLoS One 6(10):e26194. PMID:22031823

Theme3Dot Threlfell S, Cragg SJ (2011). Striatal acetylcholine-dopamine crosstalk and the dorsal-ventral divide. In: Dopamine-glutamate interactions in the basal ganglia (Ed. S. Jones), Routledge (Taylor and Francis Group), London, Chapter 6, pp 119-138




Theme3Dot Lourenço-Venda L, Cragg SJ, Buchman VL, Wade-Martins, R. (2010). α-Synuclein and dopamine at the crossroads of Parkinson’s disease, Trends Neurosci, 33:559-568. PubMed ID: 20961626