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3 themes

Theme2Dot Booth HDE, Wessely F, Connor-Robson N, Rinaldi F, Vowles J, Browne C, Evetts SG, Hu MT, Cowley SA, Webber C, Wade-Martins R. (2019) RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes. Neurobiol Dis. 129:56-66. PMID:31085228

Theme1DotTheme2DotTheme3Dot Connor-Robson N, Booth H, Martin JG, Gao B, Li K, Doig N, Vowles J, Browne C, Klinger L, Juhasz P, Klein C, Cowley SA, Bolam P, Hirst W, Wade-Martins R. (2019) An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Neurobiol Dis. 127:512-526. PMID:30954703

Theme1Dot Cooray N, Andreotti F, Lo C, Symmonds M, Hu MT, De Vos M. (2019) Detection of REM Sleep Behaviour Disorder by Automated Polysomnography Analysis. https://arxiv.org/abs/1811.04662 PMID:30440668

Theme1Dot Davis S, Scott C, Ansorge O, Fischer R. (2019) Development of a Sensitive, Scalable Method for Spatial, Cell-Type-Resolved Proteomics of the Human Brain. J Proteome Res. 18(4):1787-1795. PMID:30768908

Theme1Dot Guerreiro R, Ross OA, Kun-Rodrigues C, Hernandez DG, Orme T, Eicher JD, Shepherd CE, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Ansorge O, Clarimon J, Lleo A, Morenas-Rodriguez E, Clark L,..., Bras J. (2019) Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. Lancet Neurol. 17(1):64-74. PMID:29263008

 Theme1Dot Henderson EJ, Morgan GS, Amin J, Gaunt DM, Ben-Shlomo Y. (2019) The minimum clinically important difference (MCID) for a falls intervention in Parkinson's: A delphi study. Parkinsonism Relat Disord. 61, 106-110. PMID:30455158

Theme1Dot Hu, MT (2019) From dreams to parkinsonism: tracking the journey. Brain, 142(7), 850–1852 (commentary on ‘Evolution of prodromal Parkinson’s disease and dementia with Lewy bodies: a prospective study’ by Fereshtehnejad et al. doi:10.1093/brain/awz111)

Theme1Dot Jabbari E, Woodside J, Guo T, Magdalinou NK, Chelban V, Athauda D, Lees AJ, Foltynie T, Houlden H, Church A, Hu MT, Rowe JB, Zetterberg H, Morris HR. (2019) Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes. J Neurol Neurosurg Psychiatry. 90(7):768-773. PMID:30867224

Theme2Dot Lang C, Campbell KR, Ryan BJ, Carling P, Attar M, Vowles J, Perestenko OV, Bowden R, Baig F, Kasten M, Hu MT, Cowley SA, Webber C, Wade-Martins R. (2019) Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes. Cell Stem Cell. 24(1):93-106.e6. PMID:30503143

Theme3Dot Lopes EF, Roberts BM, Siddorn RE, Clements MA, Cragg SJ (2019) Inhibition of nigrostriatal dopamine release by striatal GABAA and GABAB receptorsJ Neurosci. PMID:30541909

Theme2Dot Nizami S, Hall-Roberts H, Warrier S, Cowley SA, Di Daniel E. (2019) Microglial inflammation and phagocytosis in Alzheimer's disease: potential therapeutic targets. Br J Pharmacol. PMID:30740661

Theme1Dot Norwitz NG, Hu MT, Clarke K. (2019) The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of Parkinson's Disease. Front Nutr. 6:63. eCollection 2019. Review. PMID:31139630

Theme3Dot Pristerà A, Blomeley C, Lopes E, Threlfell S, Merlini E, Burdakov D, Cragg S, Guillemot F, Ang SL. (2019) Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration. Proc Natl Acad Sci USA. 116(9):3817-3826. PMID:30808767

Theme3Dot Reis C, Sharott A, Magill PJ, van Wijk BCM, Parr T, Zeidman P, Friston KJ, Cagnan H. (2019) Thalamocortical dynamics underlying spontaneous transitions in beta power in Parkinsonism. Neuroimage. 193:103-114. PMID:30862535

Theme1DotTheme2Dot Stefanis L, Emmanouilidou E, Pantazopoulou M, Kirik D, Vekrellis K, Tofaris GK. (2019) How is alpha-synuclein cleared from the cell? J Neurochem. PMID:31069800

Theme1Dot Sundaresan V, Griffanti L, Kindalova P, Alfaro-Almagro F, Zamboni G, Rothwell PM, Nichols TE, Jenkinson M. (2019) Modelling the distribution of white matter hyperintensities due to ageing on MRI images using Bayesian inference. Neuroimage. 185:434-445. PMID: 30359730

Theme3Dot Szabo A, Tofaris GK. (2019) Monitoring α-Synuclein Proteotoxicity in Drosophila Models. Methods Mol Biol. 1948:199-208. PMID:30771179

Theme3Dot Wallings R, Connor-Robson N, Wade-Martins R. (2019) LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function. Hum Mol Genet. ddz088. PMID:31039583

Theme2Dot Zambon F, Cherubini M, Fernandes HJR, Lang C, Ryan BJ, Volpato V, Bengoa-Vergniory N, Vingill S, Attar M, Booth HDE, Haenseler W, Vowles J, Bowden R, Webber C, Cowley SA, Wade-Martins R. (2019) Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons. Hum Mol Genet. PMID:30753527

Theme3Dot Zhang X-M, Anwar S, Kim Y, Brown J, Comte I, Cai H, Cai N-N, Wade-Martins R, Szele FG (2019) The A30P α-synuclein mutation decreases subventricular zone proliferationHum Mol Genet. 28(14) 2283–2294. 



3 themes

Theme1Dot Andreotti F, Phan H, Cooray N, Lo C, Hu MTM, De Vos M. (2018) Multichannel Sleep Stage Classification and Transfer Learning using Convolutional Neural Networks. Conf Proc IEEE Eng Med Biol Soc. 171-174. PMID:30440365

Theme1Dot Arora S, Baig F, Lo C, Barber TR, Lawton MA, Zhan A, Rolinski M, Ruffmann C, Klein JC, Rumbold J, Louvel A, Zaiwalla Z, Lennox G, Quinnell T, Dennis G, Wade-Martins R, Ben-Shlomo Y, Little MA, Hu MT. (2018) Smartphone motor testing to distinguish idiopathic REM sleep behavior disorder, controls, and PD. Neurology. 91(16):e1528-e1538. PMID:30232246

Theme1Dot Barber TR, Griffanti L, Muhammed K, Drew DS, Bradley KM, McGowan DR, Crabbe M, Lo C, Mackay CE, Husain M, Hu MT, Klein JC; Oxford Parkinson's Disease Centre. (2018) Apathy in rapid eye movement sleep behaviour disorder is associated with serotonin depletion in the dorsal raphe nucleus. Brain. 141(10):2848-2854. PMID:30212839

Theme1Dot Brainstorm Consortium, …, Sandor C, Webber C, …, Murray R. (2018) Analysis of shared heritability in common disorders of the brain. Science. 360(6395). pii: eaap8757. PMID:29930110

Theme3Dot Brimblecombe KR, Threlfell S, Dautan D, Kosillo P, Mena-Segovia J, Cragg SJ. (2018) Targeted Activation of Cholinergic Interneurons Accounts for the Modulation of Dopamine by Striatal Nicotinic Receptors. eNeuro. 5(5). pii: ENEURO.0397-17.2018. PMID:30406189

Theme1Dot Fiandaca MS, Gross TJ, Johnson TM, Hu MT, Evetts S, Wade-Martins R, Merchant-Borna K, Bazarian J, Cheema AK, Mapstone M, Federoff HJ. (2018) Potential Metabolomic Linkage in Blood between Parkinson's Disease and Traumatic Brain Injury. Metabolites. 8(3). pii:E50. PMID:30205491

Theme2Dot Finelli MJ, Paramo T, Pires E, Ryan BJ, Wade-Martins R, Biggin PC, McCullagh J, Oliver PL. (2018) Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase. Mol Neurobiol. PMID:29905912

Theme3Dot Garas FN, Kormann E, Shah RS, Vinciati F, Smith Y, Magill PJ, Sharott A. (2018) Structural and molecular heterogeneity of calretinin-expressing interneurons in the rodent and primate striatum. J Comp Neurol. 526(5):877-898 PMID:29218729

Theme1Dot Griffanti L, Stratmann P, Rolinski M, Filippini N, Zsoldos E, Mahmood A, Zamboni G, Douaud G, Klein JC, Kivimäki M, Singh-Manoux A, Hu MT, Ebmeier KP, Mackay CE. (2018) Exploring variability in basal ganglia connectivity with functional MRI in healthy ageing. Brain Imaging and Behavior, 12(6):1822-1827. PMID: 29442271.

Theme1Dot Griffanti L, Jenkinson M, Suri S, Zsoldos E, Mahmood A, Filippini N, Sexton CE, Topiwala A, Allan C, Kivimäki M, Singh-Manoux A, Ebmeier KP, Mackay CE, Zamboni G. (2018) Classification and characterization of periventricular and deep white matter hyperintensities on MRI: A study in older adults. Neuroimage, S1053-8119(17), 30231-8. PMID: 28315460

Theme2Dot Härtlova A, Herbst S, Peltier J, Rodgers A, Bilkei-Gorzo O, Fearns A, Dill BD, Lee H, Flynn R, Cowley SA, Davies P, Lewis PA, Ganley IG, Martinez J, Alessi DR, Reith AD, Trost M, Gutierrez MG. (2018) LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages. EMBO J. 37(12). pii: e98694. PMID:29789389

Theme1Dot Hipp G, Vaillant M, Diederich NJ, Roomp K, Satagopam VP, Banda P, Sandt E, Mommaerts K, Schmitz SK, Longhino L, Schweicher A, Hanff AM, Nicolai B, Kolber P, Reiter D, Pavelka L, Binck S, Pauly C, Geffers L, Betsou F, Gantenbein M, Klucken J, Gasser T, Hu MT, Balling R, Krüger R. (2018) The Luxembourg Parkinson's Study: A Comprehensive Approach for Stratification and Early Diagnosis. (2018) Front Aging Neurosci. 10:326. PMID:30420802

Theme2Dot Jonikas M, Madill M, Mathy A, Zekoll T, Zois CE, Wigfield S, Kurzawa-Akanbi M, Browne C, Sims D, Chinnery PF, Cowley SA, Tofaris GK. (2018) Stem Cell modeling of Mitochondrial Parkinsonism reveals key functions of OPA1. Ann Neurol. PMID:29604226

Theme1Dot Klein JC, Rolinski M, Griffanti L, Szewczyk-Krolikowski K, Baig F, Ruffmann C, Groves AR, Menke RAL, Hu MT, Mackay C. (2018) Cortical structural involvement and cognitive dysfunction in early Parkinson’s disease. NMR in Biomedicine, PMID: 29436039.

Theme1Dot Lawton M, Ben-Shlomo Y, May MT, Baig F, Barber TR, Klein JC, Swallow DMA, Malek N, Grosset KA, Bajaj N, Barker RA, Williams N, Burn DJ, Foltynie T, Morris HR, Wood NW, Grosset DG, Hu MTM. (2018) Developing and validating Parkinson's disease subtypes and their motor and cognitive progression. J Neurol Neurosurg Psychiatry. 89(12):1279-1287. PMID: 30464029

Theme1Dot Le Heron C, Plant O, Manohar S, Ang YS, Jackson M, Lennox G, Hu MT, Husain M. (2018) Distinct effects of apathy and dopamine on effort-based decision-making in Parkinson's disease. Brain. 141(5):1455-1469. PMID:29672668

Theme1Dot Le Heron C, Manohar S, Plant O, Muhammed K, Griffanti L, Nemeth A, Douaud G, Markus HS, Husain M. (2018) Dysfunctional effort-based decision-making underlies apathy in genetic cerebral small vessel disease. Brain. 141(11):3193-3210. PMID:30346491

Theme1Dot Li J, Ruskey JA, Arnulf I, Dauvilliers Y, Hu MTM, Högl B, Leblond CS, Zhou S, Ambalavanan A, Ross JP, Bourassa CV, Spiegelman D, Laurent SB, Stefani A, Charley Monaca C, Cochen De Cock V, Boivin M, Ferini-Strambi L, Plazzi G, Antelmi E, Young P, Heidbreder A, Labbe C, Ferman TJ, Dion PA, Fan D, Desautels A, Gagnon JF, Dupré N, Fon EA, Montplaisir JY, Boeve BF, Postuma RB, Rouleau GA, Ross OA, Gan-Or Z. (2018) Full sequencing and haplotype analysis of MAPT in Parkinson's disease and rapid eye movement sleep behavior disorder. Mov Disord. 33(6):1016-1020. PMID:29756641

Theme1Dot Ouled Amar Bencheikh B, Ruskey JA, Arnulf I, Dauvilliers Y, Monaca CC, De Cock VC, Gagnon JF, Spiegelman D, Hu MTM, Högl B, Stefani A, Ferini-Strambi L, Plazzi G, Antelmi E, Young P, Heidbreder A, Mollenhauer B, Sixel-Döring F, Trenkwalder C, Oertel W, Montplaisir JY, Postuma RB, Rouleau GA, Gan-Or Z. (2018) LRRK2 protective haplotype and full sequencing study in REM sleep behavior disorder. Parkinsonism Relat Disord. 52:98-101. PMID:29576439

Theme2Dot Rakovic A, Domingo A, Grütz K, Kulikovskaja L, Capetian P, Cowley SA, Lenz I, Brüggemann N, Rosales R, Jamora D, Rolfs A, Seibler P, Westenberger A, König I, Klein C. (2018) Genome editing in induced pluripotent stem cells rescues TAF1 levels in X-linked dystonia-parkinsonism. Mov Disord. 33(7):1108-1118. PMID:30153385

Theme1Dot Ruffmann C, Bengoa-Vergniory N, Poggiolini I, Ritchie D, Hu MT, Alegre-Abarrategui J, Parkkinen L. (2018) Detection of alpha-synuclein conformational variants from gastro-intestinal biopsy tissue as a potential biomarker for Parkinson's disease. Neuropathol Appl Neurobiol. 44(7):722-736. PMID:29676021

Theme1Dot Silverdale MA, Kobylecki C, Kass-Iliyya L, Martinez-Martin P, Lawton M, Cotterill S, Chaudhuri KR, Morris H, Baig F, Williams N, Hubbard L, Hu MT, Grosset DG; UK Parkinson's Pain Study Collaboration. (2018) A detailed clinical study of pain in 1957 participants with early/moderate Parkinson's disease. Parkinsonism Relat Disord. 56:27-32. PMID: 29903584

Theme1Dot Smith AM, Depp C, Ryan BJ, Johnston GI, Alegre-Abarrategui J, Evetts S, Rolinski M, Baig F, Ruffmann C, Simon AK, Hu MTM, Wade-Martins R. (2018) Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells. Mov Disord. 33(10):1580-1590. PMID:30294923

Theme1Dot Tofaris GK, Buckley NJ. (2018) Convergent molecular defects underpin diverse neurodegenerative diseases. J Neurol Neurosurg Psychiatry. pii: jnnp-2017-316988. PMID: 29459380

Theme1Dot Valkanova V, Esser P, Demnitz N, Sexton CE, Zsoldos E, Mahmood A, Griffanti L, Kivimäki M, Singh-Manoux A, Dawes H, Ebmeier KP. (2018) Association between gait and cognition in an elderly population based sample. Gait Posture. 65:240-245. PMID: 30558938

Theme2Dot Volpato V, Smith J, Sandor C, ..., Webber C, Cader MZ, Lakics V. (2018) Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study. Stem Cell Reports. 11(4):897-911. PMID:30245212

Theme1Dot Watson LM, Wong MMK, Vowles J, Cowley SA, Becker EBE. (2018) A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells. Cerebellum. 17(4):419-427. PMID:29397531

Theme3Dot West TO, Berthouze L, Halliday DM, Litvak V, Sharott A, Magill PJ, Farmer SF. (2018) Propagation of beta/gamma rhythms in the cortico-basal ganglia circuits of the parkinsonian rat. J Neurophysiol. 119(5):1608-1628. PMID:29357448

Theme3Dot Zhang YF, Reynolds JNJ, Cragg SJ. (2018) Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with Dopamine Modulation. Neuron. pii: S0896-6273(18)30335-0. PMID:29754751



3 themes

Theme1Dot Alexopoulou Z, Lang J, Perrett RM, Elschami M, Hurry ME, Kim HT, Mazaraki D, Szabo A, Kessler BM, Goldberg AL, Ansorge O, Fulga TA, Tofaris GK. (2017) Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease. Proc Natl Acad Sci USA. 113(32):E4688-97. PMID:2744401

Theme1Dot Baig F, Lawton MA, Rolinski M, Ruffmann C, Klein JC, Nithi K, Okai D, Ben-Shlomo Y, Hu MTM. (2017) Personality and addictive behaviours in early Parkinson’s disease and REM sleep behavior disorder. Park Rel Dis. 37:72-78. PMID:28173973

Theme2Dot Bailey J, Shaw A, Fischer R, Ryan BJ, Kessler BM, McCullagh J, Wade-Martins R, Channon KM, Crabtree MJ. (2017) A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance. Free Radic Biol Med. 104:214-225. PMID:28104455

Theme1Dot Barber TR, Muhammed K, Drew D, Lawton M, Crabbe M, Rolinski M, Quinnell T, Zaiwalla Z, Ben-Shlomo Y, Husain M, Hu MT. (2017) Apathy in rapid eye movement sleep behaviour disorder is common and under-recognised. Eur J Neurol. doi: 10.1111/ene.13515. [Epub ahead of print] PMID:29114969

Theme1Dot Barber TR, Lawton M, Rolinski M, Evetts S, Baig F, Ruffmann C, Gornall A, Klein JC, Lo C, Dennis G, Bandmann O, Quinnell T, Zaiwalla Z, Ben-Shlomo Y, Hu MT. (2017) Prodromal Parkinsonism and neurodegenerative risk stratification in REM sleep behaviour disorder. Sleep. PMID:28472425

Theme1Dot Barber TR, Klein JC, MacKay CE, Hu MT (2017) Neuroimaging in pre-motor Parkinson's disease. NeuroImage: Clinical 15, 215–227.

Theme2Dot Baud A, Wessely F, Mazzacuva F, McCormick J, Camuzeaux S, Heywood WE, Little D, Vowles J, Tuefferd M, Mosaku O, Lako M, Armstrong L, Webber C, Cader MZ, Peeters P, Gissen P, Cowley SA and Mills K. (2017) A Multiplex High-Throughput Targeted Proteomic Assay To Identify Induced Pluripotent Stem Cells. Analytical Chemistry. 89(4):2440-2448. PMID:28192931

Theme2Dot Beevers JE, Lai MC, Collins E, Booth HDE, Zambon F, Parkkinen L, Vowles J, Cowley SA, Wade-Martins R, Caffrey TM (2017) MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons. Stem Cell Reports. 9(2):587-599. PMID: 28689993

Theme1Dot Bengoa-Vergniory N, Roberts RF, Wade-Martins R, Alegre-Abarrategui J. (2017) Alpha-synuclein oligomers: a new hope. Acta Neuropathol. PMID:28803412

Theme2Dot Booth HDE, Hirst WD, Wade-Martins R. (2017) The Role of Astrocyte Dysfunction in Parkinson's Disease Pathogenesis. Trends Neurosci. 40(6):358-370. PMID:28527591

Theme3Dot Brimblecombe KR, Cragg SJ (2017) The striosome and matrix compartments of the striatum: a path through the labyrinth from neurochemistry towards function. ACS Chem Neurosci. 8(2):235-242. PMID: 27977131

Theme2Dot Cherubini M, Wade-Martins R. (2017) Convergent pathways in Parkinson's disease. Cell Tissue Res. doi:10.1007/s00441-017-2700-2. PMID:29063175

Theme1Dot Demnitz N, Zsoldos E, Mahmood A, Mackay CE, Kivimäki M, Singh-Manoux A, Dawes H, Johansen-Berg H, Ebmeier KP, Sexton CE. (2017) Associations between Mobility, Cognition, and Brain Structure in Healthy Older Adults. Front Aging Neurosci. 9:155. PMID: 28588477

Theme3Dot Doucet M, El-Turabi A, Zabel F, Hunn BHM, Bengoa-Vergniory N, Cioroch M, Ramm M, Smith AM, Gomes AC, Cabral de Miranda G, Wade-Martins R, Bachmann MF. (2017) Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles. PLoS One. 12(8):e0181844. PMID:28797124

Theme1Dot Gan-Or Z, Montplaisir JY, Ross JY, Poirier J, Warby SC, Arnulf I, Strong S, Dauvilliers Y, Leblond CS, Hu MTM, Hogl B, Stefani A, Monaca CC, De Cock VC, Boivin M, Ferini-Stambi L, Plazzi G, Antelmi E, Young P, Heidbreber A, Barber TR, Evetts SG, Rolinski M, Dion PA, Desautels A, Gagnon J-F, Dupre N, Postuma RB, Rouleau GA. (2017) The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder. Neurobiology of Aging. 218.e13-218.e15. PMID: 27814994

Theme3Dot González-Cabrera C, Meza R, Ulloa L, Merino-Sepúlveda P, Luco V, Sanhueza A, Oñate-Ponce A, Bolam JP, Henny P. (2017) Characterization of the axon initial segment of mice substantia nigra dopaminergic neurons. J Comp Neurol. 525(16):3529-3542. PMID:28734032

Theme1Dot Griffanti L, Douaud G, Bijsterbosch J, Evangelisti S, Alfaro-Almagro F, Glasser MF, Duff EP, Fitzgibbon S, Westphal R, Carone D, Beckmann CF, Smith SM. (2017) Hand classification of fMRI ICA noise components. Neuroimage. 154:188-205. PMID: 27989777

Theme2Dot Haenseler W, Zambon F, Lee H, Vowles J, Rinaldi F, Duggal G, Houlden H, Gwinn K, Wray S, Luk KC, Wade-Martins R, James WS, Cowley SA. (2017) Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages. Sci Rep. 7(1):9003. PMID:28827786

Theme2Dot Haenseler W, Sansom SN, Buchrieser J, Newey SE, Moore CS, Nicholls FJ, Chintawar S, Schnell C, Antel JP, Allen ND, Cader MZ, Wade-Martins R, James WS, Cowley SA. (2017) A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response. Stem Cell Reports. 8(6):1727-1742. PMID:28591653

Theme2Dot Heman-Ackah SM, Manzano R, Hoozemans JJM, Scheper W, Flynn R, Haerty W, Cowley SA, Bassett AR, Wood MJA. (2017) Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons. Hum Mol Genet. 26(22):4441-4450. PMID:28973645

Theme1Dot Koychev I, Gunn RN, Firouzian A, Lawson J, Zamboni G, Ridha B, Sahakian BJ, Rowe JB, Thomas A, Rochester L, Ffytche D, Howard R, Zetterberg H, MacKay C, Lovestone S; Deep and Frequent Phenotyping study team. (2017) PET Tau and Amyloid-β Burden in Mild Alzheimer's Disease: Divergent Relationship with Age, Cognition, and Cerebrospinal Fluid Biomarkers. J Alzheimers Dis. 60(1):283-293. PMID: 28800330

Theme1Dot Kyle SD, Sexton CE, Feige B, Luik AI, Lane J, Saxena R, Anderson SG, Bechtold DA, Dixon W, Little MA, Ray D, Riemann D, Espie CA, Rutter MK, Spiegelhalder K. (2017) Sleep and cognitive performance: cross-sectional associations in the UK Biobank. Sleep Med. 38:85-91. PMID: 29031762

Theme2Dot Lai MC, Bechy AL, Denk F, Collins E, Gavriliouk M, Zaugg JB, Ryan BJ, Wade-Martins R, Caffrey TM. (2017) Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders. Mol Neurodegener. 12(1):79. PMID:29084565

Theme1Dot Lane JM, Liang J, Vlasac I, Anderson SG, Bechtold DA, Bowden J, Emsley R, Gill S, Little MA, Luik AI, Loudon A, Scheer FA, Purcell SM, Kyle SD, Lawlor DA, Zhu X, Redline S, Ray DW, Rutter MK, Saxena R. (2017) Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits. Nat Genet. 49(2):274-281. PMID: 27992416

Theme2Dot Lee H, James WS, Cowley SA (2017) LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson’s disease. Biochemical Society Transactions. 45(1):131-139. PMID:28202666

Theme1Dot Li Q, Tofaris GK, Davis JJ. (2017) Concentration-Normalized Electroanalytical Assaying of Exosomal Markers. Anal Chem. 89(5):3184-3190. PMID 28192902

Theme1Dot Lunnon K, Keohane A, Pidsley R, Newhouse S, Riddoch-Contreras J, Thubron EB, Devall M, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Schalkwyk L, Dobson R, Malik AN, Powell J, Lovestone S, Hodges A; (2017) Mitochondrial genes are altered in blood early in Alzheimer's disease. Neurobiol Aging. 53:36-47. PMID:28208064

Theme1Dot Malek N, Lawton MA, Grosset KA, Bajaj N, Barker RA, Ben-Shlomo Y, Burn DJ, Foltynie T, Hardy J, Morris HR, Williams NM, Wood N, Grosset DG; PRoBaND clinical consortium. (2017) Utility of the new Movement Disorder Society clinical diagnostic criteria for Parkinson's disease applied retrospectively in a large cohort study of recent onset cases. Parkinsonism Relat Disord. S1353-8020(17)30136-0. PMID:28431829

Theme3Dot McMillan KJ, Murray TK, Bengoa-Vergniory N, Cordero-Llana O, Cooper J, Buckley A, Wade-Martins R, Uney JB, O'Neill MJ, Wong LF, Caldwell MA. (2017) Loss of MicroRNA-7 Regulation Leads to α-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo. Mol Ther. 25(10):2404-2414. PMID:28927576

Theme3Dot Mena-Segovia J, Bolam JP (2017) Rethinking the Pedunculopontine Nucleus: From Cellular Organization to Function. Neuron. 94(1):7-18. PMID: 28384477

Theme1Dot Morgan AR, O'Hagan C, Touchard S, Lovestone S, Morgan BP. (2017) Effects of freezer storage time on levels of complement biomarkers. BMC Res Notes. 10(1):559. PMID: 29110694

Theme2Dot Sandor C, Robertson P, Lang C, Heger A, Booth H, Vowles J, Witty L, Bowden R, Hu M, Cowley SA, Wade-Martins R, Webber C. (2017) Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease. Hum Mol Genet. 26(3):552-566. PMID: 28096185

Theme2Dot Sandor C, Honti F, Haerty W, Szewczyk-Krolikowski K, Tomlinson P, Evetts S, Millin S, Keane T, McCarthy S, Durbin R, Talbot K, Hu M, Webber C, Ponting C, Wade-Martins R. (2017) Whole-exome sequencing of 228 patients with sporadic Parkinson’s disease. Scientific Reports. 7:41188. PMID:28117402

Theme1Dot Sexton CE, Zsoldos E, Filippini N, Griffanti L, Winkler A, Mahmood A, Allan CL, Topiwala A, Kyle SD, Spiegelhalder K, Singh-Manoux A, Kivimaki M, Mackay CE, Johansen-Berg H, Ebmeier KP. (2017) Associations between self-reported sleep quality and white matter in community-dwelling older adults: A prospective cohort study. Hum Brain Mapp. 38(11):5465-5473. PMID: 28745016

Theme3Dot Sharott A, Vinciati F, Nakamura KC, Magill PJ. (2017) A Population of Indirect Pathway Striatal Projection Neurons Is Selectively Entrained to Parkinsonian Beta Oscillations. J Neurosci. 37(41):9977-9998.

Theme1Dot Silva de Lima AL, Evers LJ, Hahn T, Bataille L, Hamilton JL, Little MA, Okuma Y, Bloem BR, Faber MJ. (2017) Freezing of gait and fall detection in Parkinson's disease using wearable sensors: a systematic review. J Neurol. PMID:28251357

Theme1Dot Silva de Lima AL, Hahn T, Evers LJW, de Vries NM, Cohen E, Afek M, Bataille L, Daeschler M, Claes K, Boroojerdi B, Terricabras D, Little MA, Baldus H, Bloem BR, Faber MJ. (2017) Feasibility of large-scale deployment of multiple wearable sensors in Parkinson's disease. PLoS One. 12(12):e0189161. PMID: 28847810

Theme1Dot Straniero L, Guella I, Cilia R, Parkkinen L, Rimoldi V, Young A, Asselta R, Soldà G, Sossi V, Stoessl AJ, Priori A, Nishioka K, Hattori N, Follett J, Rajput A, Blau N, Pezzoli G, Farrer MJ, Goldwurm S, Rajput AH, Duga S. (2017) DNAJC12 and dopa-responsive nonprogressive parkinsonism. Ann Neurol. 82(4):640-646. PMID: 28892570

Theme1Dot Suri S, Topiwala A, Filippini N, Zsoldos E, Mahmood A, Sexton CE, Singh-Manoux A, Kivimäki M, Mackay CE, Smith S, Ebmeier KP. (2017) Distinct resting-state functional connections associated with episodic and visuospatial memory in older adults. Neuroimage.159:122-130. PMID: 28756237

Theme1Dot Suri S, Emir U, Stagg CJ, Near J, Mekle R, Schubert F, Zsoldos E, Mahmood A, Singh-Manoux A, Kivimäki M, Ebmeier KP, Mackay CE, Filippini N. (2017) Effect of age and the APOE gene on metabolite concentrations in the posterior cingulate cortex. Neuroimage. 152:509-516. PMID: 28323160

Theme1Dot Tofaris GK. (2017) A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson's Disease. J Parkinsons Dis. 7(4):569-576. PMID: 28922170

Theme1Dot Tofaris GK, Goedert M, Spillantini MG. (2017) The Transcellular Propagation and Intracellular Trafficking of α-Synuclein. Cold Spring Harb Perspect Med. 7(9). pii: a024380. PMID: 27920026

Theme1Dot Topiwala A, Allan CL, Valkanova V, Zsoldos E, Filippini N, Sexton C, Mahmood A, Fooks P, Singh-Manoux A, Mackay CE, Kivimäki M, Ebmeier KP. (2017) Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study. BMJ. 357:j2353. PMID: 28588063

Theme3Dot Vargas-Caballero M, Denk F, Wobst HJ, Arch E, Pegasiou CM, Oliver PL, Shipton OA, Paulsen O, Wade-Martins R. (2017) Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau-/- mice. Front Neurosci. 11:201. PMID:28484365

Theme3Dot Vingill S, Connor-Robson N, Wade-Martins R. (2017) Are rodent models of Parkinson's disease behaving as they should? Behav Brain Res. pii: S0166-4328(17)30592-2. PMID:29074404

Theme1Dot Wei W, Keogh MJ, Wilson I, Coxhead J, Ryan S, Rollinson S, Griffin H, Kurzawa-Akanbi M, Santibanez-Koref M, Talbot K, Turner MR, McKenzie CA, Troakes C, Attems J, Smith C, Al Sarraj S, Morris CM, Ansorge O, Pickering-Brown S, Ironside JW, Chinnery PF. (2017) Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains. Acta Neuropathol Commun. 5(1):13. Erratum in: Acta Neuropathol Commun. 2017 Feb 22;5(1):17. PMID:28153046

Theme1Dot Westwood S, Liu B, Baird AL, Anand S, Nevado-Holgado AJ, Newby D, Pikkarainen M, Hallikainen M, Kuusisto J, Streffer JR, Novak G, Blennow K, Andreasson U, Zetterberg H, Smith U, Laakso M, Soininen H, Lovestone S. (2017) The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology. Alzheimers Res Ther. 9(1):31. PMID:28441961

Theme3Dot Wobst HJ, Denk F, Oliver PL, Livieratos A, Taylor TN, Knudsen MH, Bengoa-Vergniory N, Bannerman D and Wade-Martins R (2017) Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy. Scientific Reports. 7:43198. PMID:28233851

Theme3Dot Zhang YF, Cragg SJ. (2017) Pauses in Striatal Cholinergic Interneurons: What is Revealed by Their Common Themes and Variations? Front Syst Neurosci. 11:80. PMID: 29163075




3 themes

Theme1DotTheme3Dot Dodson PDDreyer JK, Jennings KA, Syed ECWade-Martins RCragg SJBolam JPMagill PJ (2016) Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism. PNAS, 113(15):E2180-8. PMID: 27001837.

Theme1Dot Espay AJ, Bonato P, Nahab FB, Maetzler W, Dean JM, Klucken J, Eskofier BM, Merola A, Horak F, Lang AE, Reilmann R, Giuffrida J, Nieuwboer A, Horne M, Little MA, Litvan I, Simuni T, Dorsey ER, Burack MA, Kubota K, Kamondi A, Godinho C, Daneault JF, Mitsi G, Krinke L, Hausdorff JM, Bloem BR, Papapetropoulos S. (2016) Technology in Parkinson's disease: Challenges and opportunities. Movement Disorders. PMID:27125836

Theme1Dot Fairfoul G, McGuire LI, Pal S, Ironside JW, Neumann J, Christie S, Joachim C, Esiri M, Evetts SG, Rolinski M, Baig F, Ruffmann C, Wade-Martins R, Hu MTM, Parkkinen L and Green AJE (2016) Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies. Annals of Clinical and Translational Neurology. doi: 10.1002/acn3.338

Theme2Dot Fernandes HJR, Hartfield EM, Christian HC, Emmanoulidou E, Zheng Y, Booth H, Bogetofte H, Lang CRyan BJ, Sardi SP, Badger J, Vowles J, Evetts S, Tofaris GK, Vekrellis K, Talbot K, Hu MT, James W, Cowley SA, Wade-Martins R (2016) ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons. Stem Cell Reports. 6(3):342-56.  PMID:26905200

Theme3Dot Garas FN, Shah RS, Kormann E, Doig NM, Vinciati F, Nakamura KC, Dorst MC, Smith Y, Magill PJ, Sharott A. (2016)  Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons. Elife. 5. pii: e16088. PMID:27669410

Theme1Dot Griffanti L, Rolinski M, Szewczyk-Krolikowski K, Menke RA, Filippini N, Zamboni G, Jenkinson M, Hu MT, Mackay CE. (2016) Challenges in the reproducibility of clinical studies with resting state fMRI: An example in early Parkinson's disease. Neuroimage. 2016 Jan 1; 124(Pt A): 704–713. PMID:26386348

Theme2Dot Handel AEChintawar SLalic TWhiteley EVowles JGiustacchini AArgoud KSopp PNakanishi MBowden RCowley SNewey SAkerman CPonting CPCader MZ. (2016) Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single cell transcriptomics. Human Molecular Genetics. 25(5):989-1000. PMID: 26740550.

Theme2Dot Keane H, Ryan BJ, Jackson B, Whitmore A, Wade-Martins R. (2016) Protein-protein interaction networks identify targets which rescue the MPP+ cellular model of Parkinson's disease. Sci Rep. 5:17004. PMID:26608097

Theme3Dot Kosillo P, Zhang YF, Threlfell S, Cragg SJ. (2016) Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons. Cereb Cortex. PMID:27566978

Theme1Dot Kubota K, Chen J, Little MA (2016) Machine learning for large-scale wearable sensor data in Parkinson. disease: concepts, promises, pitfalls and futures. Movement Disorders Movement Disorders. PMID:27501026

Theme1Dot Lane JM, Vlasac I, Anderson SG, Kyle SD, Dixon WG, Bechtold DA, Gill S, Little MA, Luik A, Loudon A, Emsley R, Scheer FA, Lawlor DA, Redline S, Ray DW, Rutter MK, Saxena R. (2016) Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UKBiobank. Nature Communications, 7:10889. PMID:26955885

Theme1Dot Lawton M, Hu MT, Baig F, Ruffmann C, Barron E, Swallow DM, Malek N, Grosset KA, Bajaj N, Barker RA, Williams N, Burn DJ, Foltynie T, Morris HR, Wood NW, May MT, Grosset DG, Ben-Shlomo Y. (2016) Equating scores of the University of Pennsylvania Smell Identification Test and Sniffin' Sticks test in patients with Parkinson's disease. Parkinsonism Relat Disord. S1353-8020(16)30381-9. PMID:27729202

Theme1Dot Malek N, Lawton MA, Swallow DM, Grosset KA, Marrinan SL, Bajaj N, Barker RA, Burn DJ, Hardy J, Morris HR, Williams NM, Wood N, Ben-Shlomo Y, Grosset DG; PRoBaND Clinical Consortium. (2016) Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson's disease. Mov Disord. PMID:27324570

Theme1Dot Miller KL, Alfaro-Almagro F, Bangerter NK, Thomas DL, Yacoub E, Xu J, Bartsch AJ, Jbabdi S, Sotiropoulos SN, Andersson JLR, Griffanti L, Douaud G, Okell TW, Weale P, Dragonu I, Garratt S, Hudson S, Collins R, Jenkinson M, Matthews PM & Smith SM (2016) Multimodal population brain imaging in the UK Biobank prospective epidemiological study. Nature Neuroscience. doi.10.1038/nn.4393

Theme1Dot Muhammed K, Manohar S, Ben Yehuda M, Chong TT, Tofaris G, Lennox G, Bogdanovic M, Hu M, Husain M. (2016) Reward sensitivity deficits modulated by dopamine are associated with apathy in Parkinson's disease. Brain. PMID:27452600

Theme1Dot Panouillères MT, Tofaris GK, Brown P, Jenkinson N. (2016) Intact Acquisition and Short-Term Retention of Non-Motor Procedural Learning in Parkinson's Disease. PLOS ONE. 11(2):e0149224. PMID: 26906905

Theme1Dot Y.P. Raykov, A. Boukouvalas, F. Baig, M.A. Little. (2016) What to do when K-means clustering fails: a simple yet principled alternative algorithm
PLoS Onedoi.org/10.1371/journal.pone.0162259

Theme1Dot Rolinski M, Griffanti L, Piccini P, Roussakis AA, Szewczyk-Krolikowski K, Menke RA, Quinnell T, Zaiwalla Z, Klein JC, Mackay CE, Hu MT. (2016) Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson's disease. Brain. PMID: 27297241

Theme1Dot Ruffmann C, Parkkinen L. (2016) Gut Feelings About α-Synuclein in Gastrointestinal Biopsies: Biomarker in the Making? Movement Disorders. 31(2):193-202. PMID: 26799450.

Theme1Dot Silva de Lima AL, Hahn T, de Vries NM, Cohen E, Bataille L, Little MA, Baldus H, Bloem BR, Faber MJ. (2016) Large-Scale Wearable Sensor Deployment in Parkinson's Patients: The Parkinson@Home Study Protocol. JMIR Res Protoc. 5(3):e172. PMID:27565186

Theme3Dot Sloan M, Alegre-Abarrategui J, Potgieter D, Kaufmann AK, Exley R, Deltheil T, Threlfell S, Connor-Robson N, Brimblecombe K, Wallings R, Cioroch M, Bannerman DM, Bolam JP, Magill PJ, Cragg SJ, Dodson PD, Wade-Martins R (2016)LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function. Human Molecular Genetics. 25(5):951-63. PMID: 26744332

Theme1Dot Swallow DM, Lawton MA, Grosset KA, Malek N, Klein J, Baig F, Ruffmann C, Bajaj NP, Barker RA, Ben-Shlomo Y, Burn DJ, Foltynie T, Morris HR, Williams N, Wood NW, Hu MT, Grosset DG. (2016) Statins are underused in recent-onset Parkinson's disease with increased vascular risk: findings from the UK Tracking Parkinson's and Oxford Parkinson's Disease Centre (OPDC) discovery cohorts. J Neurol Neurosurg Psychiatry. 87(11):1183-1190. PMID:27671901

Theme1Dot Tofaris GK, Goedert M, Spillantini MG. (2016) The Transcellular Propagation and Intracellular Trafficking of α-Synuclein. Cold Spring Harb Perspect Med. pii: a024380. PMID:27920026

Theme2DotVazquez-Arango P, Vowles J, Browne C, Hartfield E, Fernandes HJ, Mandefro B, Sareen D, James W, Wade-Martins R, Cowley SA, Murphy S, O'Reilly D. (2016) Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease. Nucleic Acids Res.  pii: gkw711. PMID:27536002



3 themes

Theme3Dot Abdi A, Mallet N, Mohamed FY, Sharott A, Dodson PD, Nakamura KC, Suri S, Avery S V., Larvin JT, Garas FN, Garas SN, Vinciati F, Morin S, Bezard E, Baufreton J, Magill PJ. (2015) Prototypic and Arkypallidal Neurons in the Dopamine-Intact External Globus Pallidus.  J Neurosci 35:6667–6688. PMID: 25926446

Theme1Dot Antoniades CA, Demeyere N, Kennard C, Humphreys GW, Hu MT. (2015) Antisaccades and executive dysfunction in early drug-naive Parkinson's disease: The discovery study. Mov Disord. 30(6):843-7. PMID: 25600361

Theme1Dot Baig F, Lawton M, Rolinski M, Ruffmann C, Nithi K, Evetts SG, Fernandes HR, Ben-Shlomo Y, Hu MT. (2015) Delineating Non-Motor Symptoms in Early Parkinson’s Disease and First Degree Relatives. Mov Disord. 30(13):1759-66. PMID:26179331

Theme3Dot Brimblecombe KR, Gracie CJ, Platt NJ, Cragg SJ (2015) Gating of dopamine transmission by calcium and axonal N, Q, T and L-type voltage-gated calcium channels differs between striatal domains. J Physiol. 593: 929-946. PMID: 25533038

Theme1Dot Chong T.T, Bonnelle V, Manohar S, Veromann K.R, Muhammed K, Tofaris G.K, Hu MT, Husain M. (2015) Dopamine enhances willingness to exert effort for reward in Parkinson’s disease. Cortex, 69:40-46. PMID: 25967086

Theme3Dot Dodson PD, Larvin JT, Duffell JM, Garas FN, Doig NM, Kessaris N, Duguid IC, Bogacz R, Butt SJ, Magill PJ. (2015) Distinct developmental origins manifest in the specialized encoding of movement by adult neurons of the external globus pallidus. Neuron. 86(2):501-13. PMID: 25843402

Theme1Dot Griffanti L, Rolinski M, Szewczyk-Krolikowski K, Menke RA, Filippini N, Zamboni G, Jenkinson M, Hu MT, Mackay CE. (2015) Challenges in the reproducibility of clinical studies with resting state fMRI: An example in early Parkinson's disease. Neuroimage. 124(Pt A):704-13. PMID:26386348

Theme1Dot Guerreiro REscott-Price VDarwent LParkkinen L, Ansorge OHernandez DGNalls MAClark LHonig LMarder Kvan der Flier WHolstege HLouwersheimer ELemstra AScheltens PRogaeva ESt George-Hyslop PLondos EZetterberg HOrtega-Cubero SPastor PFerman TJGraff-Radford NRRoss OABarber IBraae ABrown KMorgan KMaetzler WBerg DTroakes CAl-Sarraj SLashley T,Compta YRevesz TLees ACairns NJHalliday GMMann DPickering-Brown SPowell JLunnon KLupton MKInternational Parkinson's Disease Genomics Consortium (IPDGC)Dickson DHardy JSingleton ABras J. (2015) Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases. Neurobiology of Aging. 38:214.e7-10. PMID:26643944

Theme3Dot Hunn BHM, Cragg SJ, Bolam JP, Spillantini MG, Wade-Martins R (2015). Impaired intracellular trafficking defines early Parkinson’s disease. Trends Neurosci. 38:178-188. PMID: 2563977

Theme2Dot Keane HRyan BJ, Jackson B, Whitmore A, Wade-Martins R (2015). Protein-protein interaction networks identify targets which rescue the MPP(+) cellular model of Parkinson's disease. Scientific Reports. 5:17004. PMID:26608097

Theme3Dot Kosillo P, Brimblecombe K, Threlfell S, Cragg SJ (2015). Coupling optogenetics with voltammetry. In: Compendium of In Vivo Monitoring in Real-Time Molecular Neuroscience: Volume 1 - Fundamentals and Applications (Eds GS Wilson, AC Michael), World Scientific Publishing Co., Singapore, 2014, Ch 9, pp 201-223,

Theme1Dot Lawton M, Baig F, Rolinski M, Ruffman C, Nithi K, May MT, Ben-Shlomo Y, Hu MT (2015) Parkinson's Disease Subtypes in the Oxford Parkinson Disease Centre (OPDC) Discovery Cohort. Journal of Parkinson's Disease 5, p269-279. PMID:26405788

Theme3Dot Pristerà A, Lin W, Kaufmann A-K, Brimblecombe KR, Threlfell S, Dodson PD, Magill PJ, Fernandes C, Cragg SJ, and Ang S-L (2015) Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice. PNAS, 112(35):E4929-38. PMID 26283356

Theme1DotTheme2Dot Roberts  RF, Wade-Martins R, Alegre-Abarrategui J (2015) Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain. Brain, 138(Pt 6):1642-57. PMID:25732184

Theme1Dot Rolinski M, Griffanti L, Szewczyk-Krolikowski K, Menke R, Wilcock G, Filippini N, Zamboni G, Hu MT, Mackay CE (2015) Aberrant functional connectivity within the basal ganglia of patients with Parkinson's disease. NeuroImage: Clinical, 8: 126-132. PMID:26106536

Theme1Dot Rolinski MZokaei NBaig FGiehl KQuinnell TZaiwalla ZMackay CEHusain MHu MT (2015) Visual short-term memory deficits in REM sleep behaviour disorder mirror those in Parkinson’s disease. Brain. 139(Pt 1):47-53. PMID:26582557

Theme2Dot Ryan BJ, Crabtree MJ, Channon KM and Wade-Martins R (2015) Letter to editor: Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers. Brain. 138(Pt 5):e348. PMID: 25398233

Theme2Dot Ryan BJ, Hoek S, Fon EA, Wade-Martins R. (2015) Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease. Trends Biochem Sci. 40(4): 200–210. PMID:25757399

Theme2Dot Silva AM, Brown JM, Buckle VJ, Wade-Martins R and Lufino MMP (2015) Expanded GAA repeats impair FXN gene expression and reposition the FXN locus to the nuclear lamina in single cells. Human Molecular Genetics; 24(12):3457-71. PMID: 25814655

Theme1Dot Stephenson D, Hu MT, Romero K, Breen K, Burn D, Ben-Shlomo Y, Bhattaram A, Isaac M, Venuto C, Kubota K, Little MA, Friend S, Lovestone S, Morris HR, Grosset D, Sutherland M, Gallacher J, Williams-Gray C, Bain LJ, Avilés E, Marek K, Toga AW, Stark Y, Forrest Gordon M, Ford S. (2015) Precompetitive Data Sharing as a Catalyst to Address Unmet Needs in Parkinson's Disease. Journal of Parkinson's Disease 5(3):581-94 PMID:26406139

Theme1Dot Tomlinson PR, Zheng Y, Fischer R, Heidasch R, Gardiner C, Evetts S, Hu M, Wade-Martins R, Turner M.R., Morris J, Talbot K, Kessler KM and Tofaris GK (2015) Identification of distinct circulating exosomes in Parkinson's disease. Annals of Clinical and Translational Neurology.
2(4):353-61. PMID:25909081

Theme1Dot Vaikath NN, Majbour NK, Paleologou KE, Ardah MT, van  Dam E, van  de  Berg WDJ, Forrest SL, Parkkinen L, Gai W-P, Hattori N, Takanashi,  Lee S-J, Mann DMA, Imai Y, Halliday GM, Li J-Y, El-Agnaf OMA (2015) Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology. Neurobiology of Diseases. 79:81-99. PMID:25937088



3 themes

Theme1Dot Alafuzoff I, Parkkinen L. (2014) Staged pathology in Parkinson's Disease. Parkinsonism & Related Disorders. 20(S1): S57-61. PMID:24262190

Theme2Dot Badger JL, Cordero-Llana O, Hartfield EM, Wade-Martins R. (2014) Parkinson's Disease in a dish - using stem cells as a molecular tool. Neuropharmacology. 76(A) 88-96. PMID:24035919

Theme1Dot Bras J, Guerreiro R, Darwent L, Parkkinen L, Ansorge O, Escott-Price V, Hernandez  DG, Nalls M, Clark L, Honig L, Marder K, van der Flier W, Lemstra E, Scheltens P, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Ortega-Cubero S, Pastor P, Ferman TJ, Graff-Radford NR, Ross OA, Barber I, Braae A, Brown K, Morgan K, Maetzler W, Berg D, Troakes C, Al-Sarraj S, Lashley T, ComptaY, Revesz T, Lees A, Cairns N, Halliday GM, Mann D, Pickering-Brown S, Dickson D, Singleton S, Hardy J (2014) Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of Dementia with Lewy Bodies. Hum Mol Genet. 23(23):6139-46. PMID:24973356

Theme1Dot Compta Y, Parkkinen L, Kempster P, Selikhova M, Lashley T, Holton JL, Lees AJ, Revesz T. (2014) The Significance of α-Synuclein, Amyloid-β and Tau Pathologies in Parkinson's Disease Progression and Related Dementia. Neurodegener Dis. 13(2-3) 154-6. PMID:24028925

Theme1Dot Davies SE, Hallett PJ, Moens T, Smith G, Mangano E, Kim HT, Goldberg AL, Liu JL, Isacson O, Tofaris GK. (2014) Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease. Neurobiol Dis. 64:79-87. PMID:24388974

Theme2Dot Hartfield, E.M., Yamasaki-Mann, M., Ribeiro Fernandes, H.J., Vowles, J., James, W.S., Cowley, S.A. and Wade-Martins, R. (2014) Physiological characterisation of human iPS-derived dopaminergic neurons. PLoS ONE 9(2): e87388 PMID:24586273

Theme3Dot Henny P, Brown MT, Micklem BR, Magill PJ, Bolam JP. (2014) Stereological and ultrastructural quantification of the afferent connectome of individual neurons. Brain Struct Funct. 219(2):631-40 PMID: 23479177

Theme1Dot Hu M, Szewczyk-Krolikowski K, Tomlinson P, Nithi K, Rolinski M, Murray C, Talbot K, Ebmeier K, Ben-Shlomo Y. (2014) Predictors of cognitive impairment in an early stage Parkinson’s disease cohort.  Movement Disorders. 29(3):351-9 PMID:24395708

Theme3Dot Martinez-Gonzalez C, van Andel J, Bolam JP, Mena-Segovia J. (2014) Divergent motor projections from the pedunculopontine nucleus are differentially regulated in Parkinsonism. Brain Struct Funct. 219(4):1451-62. PMID:23708060

Theme1Dot Menke RA, Szewczyk-Krolikowski K, Jbabdi S, Jenkinson M, Talbot K, Mackay CE, Hu M. (2014) Comprehensive morphometry of subcortical grey matter structures in early-stage Parkinson's disease. Hum Brain Mapp. 35(4): 1681-90. PMID:23861334

Theme3Dot Nevado-Holgado, A.J., Mallet, N., Magill, P.J., Bogacz, R. (2014) Effective connectivity of the subthalamic nucleus-globus pallidus network during Parkinsonian oscillations. Journal of Physiology. 592(Pt 7):1429-55. PMID:  24344162 See comment (Slaves to the rhythm: coupling of the subthalamic nucleus–globus pallidus network in Parkinsonian oscillations)

Theme1Dot Parkkinen L, Lees AJ. (2014) Is levodopa toxic? Insights from pathological studies. Focus on Parkinson’s Disease. 24(1): 16 – 20.

Theme2Dot Roberts TC, Morris KV, Wood MJ. (2014) The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease.
Philos Trans R Soc Lond B Biol Sci. 369(1652). pii: 20130507. PMID: 25135968

Theme1Dot Rolinski M, Szewczyk-Krolikowski K, Tomlinson PR, Nithi K, Talbot K, Ben-Shlomo Y, Hu MT. (2014) REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease. J Neurol Neurosurg Psychiatry. 85(5):560-6. PMID:24187013

Theme2Dot Ryan BJ, Lourenço-Venda L, Crabtree MJ, Hale AB, Channon KM and Wade-Martins R. (2014) α-synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of PD. Free Radical Biology and Medicine 67:58-68. PMID:24148766

Theme1Dot Szewczyk-Krolikowski K, Menke RAL, Rolinski M, Duff E, Salimi-Khorshidi G, Filippini N, Zamboni G, Hu MTM and Mackay CE (2014) Functional connectivity in the basal ganglia network differentiates PD patients from controls. Neurology, 83(3): 208–214. PMID:24920856

Theme1Dot Szewczyk-Krolikowski K, Tomlinson P, Nithi K, Wade-Martins, R., Talbot K, Ben-Shlomo Y and Hu M (2014) The influence of age and gender on motor and non-motor features of early Parkinson's disease: Initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort.  Parkinsonism & Related Disorders 20(1):99-105. PMID:24183678

Theme3Dot Taylor TN, Potgieter D, Anwar S, Senior SL, Janezic S, Threlfell S, Parkkinen L, Livieratos A, Oliver PL, Jennings KA, Davies KE, Ansorge O, Bannerman DM, Cragg SJ, Wade-Martins R. (2014) Region-specific deficits in dopaminergic, but not norepinephrinergic, signaling in a novel A30P-synuclein BAC transgenic mouse. Neurobiol Dis. 62(100): 193–207. PMID:24121116

Theme1Dot Xu Q, Evetts S, Hu M, Talbot KWade-Martins R, Davis JJ (2014). An impedimetric assay of α-synuclein autoantibodies in early stage Parkinson's disease. RSC Advances 4(102): 58773-58777. DOI: 10.1039/C4RA10100F

Theme1Dot Zokaei N, McNeill A, Proukakis C, Beavan M, Jarman P, Korlipara P, Hughes D, Mehta A, Hu MT, Schapira AH, Husain M. (2014) Visual short-term memory deficits associated with GBA mutation and Parkinson's disease. Brain, 137(8): 2303-11. PMID:24919969



3 themes
Theme2Dot Beevers, J.E., Caffrey, T.M., Wade-Martins, R. (2013) Induced pluripotent stem-cell (iPSC)-derived dopaminergic models of Parkinson's disease. Biochem. Soc. Trans. 41(6). PMID:24256244

Theme1Dot Douaud G, Menke RA, Gass A, Monsch AU, Rao A, Whitcher B, Zamboni G, Matthews PM, Sollberger M, Smith S. (2013) Brain microstructure reveals early abnormalities more than two years prior to clinical progression from mild cognitive impairment to Alzheimer's disease. J Neurosci. 30;33(5):2147-55. PMID: 23365250

Theme2Dot Heman-Ackah SM, Hallegger M, Rao MS, Wood MJ. (2013) RISC in PD: the impact of microRNAs in Parkinson's disease cellular and molecular pathogenesis. Front Mol Neurosci. 20;6:40. PMID:24312000

Theme3Dot Janezic S, Threlfell S, Dodson PD, Dowie MJ, Taylor TN, Potgieter D, Parkkinen L, Senior SL, Anwar S, Ryan B, Deltheil T, Kosillo P, Cioroch M, Wagner K, Ansorge O, Bannerman DM, Bolam JP, Magill PJ, Cragg SJ, Wade-Martins R. (2013) Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson’s model. Proc Natl Acad Sci USA. 110(24) PMID:24082145

Theme2Dot Lufino MM, Silva AM, Németh AH, Alegre-Abarrategui J, Russell AJ, Wade-Martins R. (2013) A GAA repeat expansion reporter model of Friedreich's ataxia recapitulates the genomic context and allows rapid screening of therapeutic compounds. Hum Mol Genet. 22(25):5173-87. PMID: 23943791

Theme2Dot Ryan BJ, Lourenço-Venda L, Crabtree MJ, Hale AB, Channon KM and Wade-Martins R (2013) α-synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of PD. Free Radic Biol Med. 67C:58-68. PMID: 24148766

Theme2Dot Thomas M, Alegre-Abarrategui J, Wade-Martins R. (2013) RNA dysfunction and aggrephagy at the centre of an amyotrophic lateral sclerosis/frontotemporal dementia disease continuum. Brain. 136(Pt 5): 1345-60. PMID:23474849

Theme3Dot Threlfell S, West AR. (2013) Review: Modulation of striatal neuron activity by cyclic nucleotide signaling and phosphodiesterase inhibition. Basal Ganglia. 3(3):137-146. PMID: 24490129

Theme2Dot van Wilgenburg B, Browne C, Vowles J, Cowley SA. (2013) Efficient, Long Term Production of Monocyte-Derived Macrophages from Human Pluripotent Stem Cells under Partly-Defined and Fully-Defined Conditions. PLoS One. 8(8):e71098. PMID:23951090



3 themes

Theme3Dot Bolam, J.P. and Pissadaki, E. (2012) Living on the edge with too many mouths to feed: why dopamine neurons die. Movement Disorders. 27(12):1478-83. PMID:23008164

Theme2Dot Hartfield, E. M., Fernandes, H. J., Vowles, J., Cowley, S. A., and Wade-Martins, R. (2012). Cellular reprogramming: a new approach to modelling parkinson's disease. Biochemical Society Transactions, 40(5):1152-1157. PMID:2298888

Theme1Dot Menke RA, Abraham I, Thiel CS, Filippini N, Knight S, Talbot K, Turner MR. (2012) Fractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis. Arch Neurol. 69(11):1493-9. PMID: 22910997

Theme2Dot Sibley CR, Seow Y, Curtis H, Weinberg MS and Wood MJA. (2012) Silencing of Parkinson's disease associated genes with artificial mirtron mimics of miR-1224. Nucleic Acids Res. 40(19):9863-75. PMID: 22848108

Theme3Dot Sloan M, Alegre-Abarrategui J, Wade-Martins R. (2012) Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models. Biochem Soc Trans. 2012 40:1080-5. PMID: 22988869

Theme3Dot Threlfell S, Lalic T, Platt NJ, Jennings KA, Deisseroth K, Cragg SJ. (2012) Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons. Neuron 75:58-64. PMID:22794260 (See Preview by Surmeier and Graybiel (2012) Neuron 75:1-3)

Theme1Dot Tofaris GK. (2012) Lysosome-dependent pathways as a unifying theme in Parkinson’s disease. Mov. Disorders Sep 15;27(11):1364-9. PMID:22927213



3 themes

Theme3Dot Anwar S, Peters O, Millership S, Ninkina N, Doig N, Connor-Robson N, Threlfell S, Kooner G, Deacon RM, Bannerman DM, Bolam JP, Chandra SS, Cragg SJ, Wade-Martins R, Buchman VL. (2011) Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family. J Neurosci. 31(20):7264-74. PMID:21593311

Theme1Dot Compta Y*, Parkkinen L*, O'Sullivan SS, Vandrovcova J, Holton JL, Collins C, Lashley T, Kallis C, Williams DR, de Silva R, Lees AJ, Revesz T (*authors contributed equally) (2011)  Lewy- and Alzheimer type pathologies in Parkinson's disease dementia: which is more important? Brain. 134:1493-505. PMID: 21596773

Theme1Dot Gallagher DA, Parkkinen L, O'Sullivan SS, Spratt A, Shah A, Davey CC, Bremner FD, Revesz T, Williams DR, Lees AJ, Schrag A. (2011) Testing an aetiological model of visual hallucinations in Parkinson's disease. Brain. 134(Pt 11):3299-309. PMID: 21921019

Theme1Dot Hu MT, Butterworth R, Kumar V, Cooper J, Jones E, Catterall L, Ben-Shlomo Y (2011) How common and what are the determinants of sub-optimal care for Parkinson's disease patients: the Milton Keynes community study. Parkinsonism Relat Disord. 17(3):177-81. PMID:21239210

Theme1Dot Hu M, Cooper J, Beamish R, Jones E, Butterworth R, Catterall L, Ben-Shlomo Y. (2011) How well do we recognise non-motor symptoms in a British Parkinson's disease population? J Neurol. 258(8):1513-7. PMID: 21394490

Theme1Dot Parkkinen L, O'Sullivan S, Kuoppamaki M, Holton JL, Revesz T, Lees AJ. (2011) Does levodopa accelerate the pathologic process in Parkinson disease brain? Neurology. 77(15):1420-6. PMID:21917769

Theme1Dot Parkkinen L, O’Sullivan S, Collins C, Petrie A, Holton JL, Revesz T, Lees AJ. (2011) Disentangling the relationship between Lewy bodies and nigral neuronal loss in Parkinson’s disease. Journal of Parkinson’s Disease (3):277-86. PMID:23939308

Theme3Dot Rice ME, Patel JC, Cragg SJ (2011). Dopamine release in the basal ganglia. Neuroscience, 198:112-37. PMID:21939738

Theme2Dot Sibley CR, Wood MJA. (2011) Identification of allele-specific RNAi effectors targeting genetic forms of Parkinson’s disease. PLoS One 6(10):e26194. PMID:22031823

Theme3Dot Threlfell S, Cragg SJ (2011). Striatal acetylcholine-dopamine crosstalk and the dorsal-ventral divide. In: Dopamine-glutamate interactions in the basal ganglia (Ed. S. Jones), Routledge (Taylor and Francis Group), London, Chapter 6, pp 119-138


Theme3Dot Lourenço-Venda L, Cragg SJ, Buchman VL, Wade-Martins, R. (2010). α-Synuclein and dopamine at the crossroads of Parkinson’s disease, Trends Neurosci, 33:559-568. PubMed ID: 20961626