Dr Pierre-Herve Luppi has been devoted to the study of the neuronal network responsible for (REM) paradoxical sleep and its dysfunctions occurring in REM sleep behavior disorder and narcolepsy since 1983. He is a specialist in REM sleep atonia, a subject relevant to cataplexy of narcoleptics, RBD and sleep apnea. He is also actively trying to identify the function of paradoxical (REM) sleep. He is currently using optogenetic and chemogenetic to resolve these questions.
• Neuronal mechanisms of the sleep-wake cycle: identification of brain structures and their interconnections involved in the genesis, maintenance and homeostasis of sleep, especially paradoxical (REM) sleep in normal conditions and animal models of sleep disorders.
• The function of sleep, particularly the role of paradoxical sleep in memory consolidation: multi-level (behavior, network, cellular) investigation of the beneficial role of sleep in learning and memory.
• The impact of sleep on mood regulation and depression.