OPDC Parkinson's Research Update 2018

On September 10th  2018 over 200 members of our Discovery cohort came to the Jury’s Inn, Oxford to hear about our latest research and share their views. We would like to thank all of the cohort members who came to the event from our centres across the country, and joined in the lively discussion session.

We have filmed the talks from the afternoon and they are available to view here:

Michele Hu - Welcome

Dr Michele Hu, OPDC clinical lead opens the 2018 Participants' Day.


Christine Lo & Claire El-Mouden Update on the Discovery Wearable Studies

Christine Lo from Oxford Parkinson's Disease Centre & Claire El-Mouden are working on projects to use technology to better monitor Parkinson's. Claire is setting up a sleep study which aims to improve diagnosis and monitoring of sleep by using at at-home monitoring system. The study is recruiting people with Parkinson's and/or REM Sleep Behaviour Disorder (RBD) for the study. For further information about taking part, please email sleep.wearables@nhs.net

Christine is working on developing our smartphone app which uses movement and sound sensors within a smartphone to monitor Parkinson's progression. They have already shown they can distinguish people with Parkinson's, people with REM Sleep disorder and healthy controls. They are now hoping to roll out the app and are looking for volunteers. To learn more please email sleep.wearables@nhs.net.

Djordje Gveric Parkinson’s UK Brain Bank - A vital gift

Djordje Gveric from the Parkinson’s Tissue Bank at Imperial College London discusses the importance of brain donation to Parkinson's research. You can learn more about brain donation, including how to register here.

View slides from Djordje Gveric's talk on the Brain Bank

Laura Parkkinen - A new test for Parkinson's

Dr Laura Parkkinen heads the Neuropathology arm of OPDC. Here she discusses a new test for Parkinson’s that measures the “stickiness” of alpha-synuclein; one of the key proteins in Parkinson's, in the cerebrospinal fluid (CSF). This same protein forms sticky clumps known as Lewy bodies within the brain cells of people with Parkinson's and dementia with Lewy bodies (DLB). Read more about the test here.


Francesca Bowring - Centre-PD Top 10 Priorities for Parkinson’s Research Study

Francesca Bowring, is a research nurse within the discovery project and project manager for Centre-PD. She is working to produce an up-to-date survey to reflect what current participants in Parkinson’s research and their friends/family would most like answered by research. If you would like participate, you can: Download the survey and post/scan it to Francesca or; Fill in the online version

Dr Mark Kelly - How common are Parkinson’s dyskinesia in the Discovery Cohort?

Dr. Mark Kelly is a researcher at the Oxford Parkinson’s Disease Centre. His research with the Oxford Discovery Project, led by Professor Michele Hu, focuses on the side effects of dopaminergic therapies, including impulse control behaviours, exploring the predictors of the effects, and clinically characterizing the impact they have on patients.

Dr Brent Ryan - Screen your stem cell: Drug discovery for Parkinson's

Dr Brent Ryan is working with the Oxford Parkinson's Disease Centre to grow cells in the lab using skin biopsy samples donated by our cohort members. He is then looking at differences in cells from people with Parkinson's and healthy controls to look for new Parkinson's drug therapies.

Michael Lawton - Defining Parkinson's Subtypes

Michael Lawton is a medical statistician working for the Oxford Parkinson's Disease Centre at Bristol University's School of Social and Community Medicine. Here he explains how he using statistical methods with the OPDC cohort and the Tracking Parkinson's Study to look for patterns in Parkinson's and better define subtypes of the condition.