The Oxford Parkinson's Disease Centre offers attractive opportunities to work with leading researchers in advancing the understanding of Parkinson's.
To discuss research opportunities with OPDC email firstname.lastname@example.org
Closing Date: Aug 8 2019 12:00:00 GMT+0100 (GMT Daylight Time) | Grade 7: £32,236 - £39,609 p.a.
An exciting opportunity has been created for two Senior Postdoctoral Scientists to join the interdisciplinary research programme studying Parkinson’s disease and related synucleinopathies in the Nuffield Department of Clinical Neurosciences led by Associate Professor Laura Parkkinen. The group focuses on elucidating biochemical and genetic signatures in human brain and biosamples to assist with understanding disease pathogenesis but also to provide diagnostic biomarkers for Parkinson’s disease and dementia. These are much needed to improve early diagnosis of PD and assessing the efficacy of disease-modifying therapies in a biologically-targeted manner.
The postholders will develop alpha-synuclein seeding assay (RT-QulC) as an early predictive biomarker, monitoring disease progression and stratifying between different synucleinopathies and examine their toxicity and infectivity in vitro. They will also perform genome-wide quantitative trait analyses using neuropathological endophenotypes to elucidate the genetic variants that may drive the propagation of Parkinson’s related pathology and generate “pseudotime” cellular atlas of substantia nigra through the progression of disease.
The postholders must hold a PhD in molecular neurosciences or in a field directly relevant to translational neuroscience. They must have substantial experience in protein chemistry, cell culture, molecular genetics and neuropathology. Previously demonstrated research acumen, a track record of successful publication(s) and clear potential for future success is vital.A less experienced candidate may be appointed at Grade 6 (£28,660 - £34,189 p.a.) with a commensurate adjustment in selection criteria, responsibilities, duties and job title.
Closing Date: Fri Aug 09 2019 12:00:00 GMT+0100 (GMT Daylight Time) | Grade 6: £28,660 - £31,302 p.a.
Applications are invited for a Research Assistant neuronal cell biologist to work at the Oxford Parkinson's Disease Centre (OPDC) to perform studies on disease mechanisms and target discovery in induced pluripotent stem cell (iPSC)-derived neuronal models of Parkinson’s disease (PD).
This is an exciting opportunity to build on previous published studies of disease mechanisms to develop the gene regulator HDAC4 as a novel therapeutic target for PD (Lang et al., Cell Stem Cell 2019). The work will be highly translational and, in collaboration with the Oxford Drug Discovery Institute, we will work to validate HDAC4 and further develop it as a new target for treatment.
Duties will include interpretation of data; design and implementation of experiments; analysis of cell biology and gene expression in iPSC-derived neurons, and other cell models; and preparation of data for publication. You will have excellent practical experience of working with neuronal cell cultures and good knowledge of cellular models of neurodegenerative disease. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is also essential. Applicants must have a good undergraduate degree and/or Masters degree in a biological subject and have experience in cellular neuroscience, cell biology or biochemistry.
The post is funded for 1 year and is available to start as soon as possible. The post will be based in the Laboratory of Molecular Neurodegeneration, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX.
Informal enquiries may be directed Professor Richard Wade-Martins (email@example.com).
Closing Date: Fri Aug 16 2019 12:00:00 GMT+0100 (GMT Daylight Time) | Grade 6: £28,660 - £32,236 p.a.
An exciting opportunity to join a thriving and dynamic research group dedicated to defeating diseases of the brain has arisen. Applications are invited for a Group Administrator to work 4 days per week (or equivalent at 80% FTE) to join the Department of Physiology, Anatomy and Genetics to support major research programmes including OPDC.The postholder will provide top-level administrative support for all research programmes held by Professor Richard Wade-Martins, including two major initiatives: the Oxford Parkinson’s Disease Centre (OPDC; www.opdc.ox.ac.uk) at the University of Oxford, and the Oxford Alzheimer’s Research UK Network (www.oxdare.ox.ac.uk/aruk) at the University of Oxford and the University of Reading. These complex partnerships involve scientists and clinicians across several areas and require administrative support to help drive forward and coordinate the research programs. The postholder will coordinate research and management meetings between principal investigators; collate scientific reports; monitor and report on grant spend; arrange seminar series; undertake public engagement, including liaising with patients, their carers and families; interact with Parkinson’s UK and Alzheimer’s Research UK, our principal funders; develop and maintain content for the website and other publicity materials; and work across the research groups to ensure the satisfactory completion of agreed milestones towards the projects’ aims.